The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity
| dc.contributor.author | Wilkinson, S. | |
| dc.contributor.author | Gunosewoyo, Hendra | |
| dc.contributor.author | Barron, M. | |
| dc.contributor.author | Boucher, A. | |
| dc.contributor.author | McDonnell, M. | |
| dc.contributor.author | Turner, P. | |
| dc.contributor.author | Morrison, D. | |
| dc.contributor.author | Bennett, M. | |
| dc.contributor.author | McGregor, I. | |
| dc.contributor.author | Rendina, L. | |
| dc.contributor.author | Kassiou, M. | |
| dc.date.accessioned | 2017-01-30T12:51:35Z | |
| dc.date.available | 2017-01-30T12:51:35Z | |
| dc.date.created | 2014-06-17T20:00:15Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | Wilkinson, S. and Gunosewoyo, H. and Barron, M. and Boucher, A. and McDonnell, M. and Turner, P. and Morrison, D. et al. 2014. The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity. ACS Chemical Neuroscience. 5 (5): pp. 335-339. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/26070 | |
| dc.identifier.doi | 10.1021/cn500054n | |
| dc.description.abstract |
Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity | |
| dc.publisher | American Chemical Society | |
| dc.subject | polycycle | |
| dc.subject | blood-brain barrier | |
| dc.subject | antidepressant | |
| dc.subject | P2X7 | |
| dc.subject | Carborane | |
| dc.title | The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity | |
| dc.type | Journal Article | |
| dcterms.source.volume | 5 | |
| dcterms.source.startPage | 335 | |
| dcterms.source.endPage | 339 | |
| dcterms.source.issn | 1948-7193 | |
| dcterms.source.title | ACS Chemical Neuroscience | |
| curtin.department | School of Pharmacy | |
| curtin.accessStatus | Fulltext not available |