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    Burn injury, gender and cancer risk: population-based cohort study using data from Scotland and Western Australia

    213573_143579_Publication.pdf (687.3Kb)
    Access Status
    Open access
    Authors
    Duke, Janine
    Bauer, J.
    Fear, M.
    Rea, S.
    Wood, F.
    Boyd, James
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Duke, J. and Bauer, J. and Fear, M. and Rea, S. and Wood, F. and Boyd, J. 2014. Burn injury, gender and cancer risk: population-based cohort study using data from Scotland and Western Australia. BMJ Open. 4 (1): Article ID e003845.
    Source Title
    BMJ Open
    DOI
    10.1136/bmjopen-2013-003845
    ISSN
    2044-6055
    School
    Centre for Population Health Research
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons License http://creativecommons.org/licenses/by-nc/3.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/26674
    Collection
    • Curtin Research Publications
    Abstract

    Objective: To investigate the risk of cancer and potential gender effects in persons hospitalised with burn injury. Design: Population-based retrospective cohort study using record-linkage systems in Scotland and Western Australia. Participants: Records of 37 890 and 23 450 persons admitted with a burn injury in Scotland and Western Australia, respectively, from 1983 to 2008. Deidentified extraction of all linked hospital morbidity records, mortality and cancer records were provided by the Information Service Division Scotland and the Western Australian Data Linkage Service. Main outcome measures: Total and gender-specific number of observed and expected cases of total (‘all sites’) and site-specific cancers and standardised incidence ratios (SIRs).Results: From 1983 to 2008, for female burn survivors, there was a greater number of observed versus expected notifications of total cancer with 1011 (SIR, 95% CI 1.3, 1.2to 1.4) and 244 (SIR, 95% CI 1.12, 1.05 to 1.30), respectively, for Scotland and Western Australia. No statistically significant difference in total cancer risk was found for males. Significant excesses in observed cancers among burn survivors (combined gender) in Scotland and Western Australian were found for buccal cavity, liver, larynx and respiratory tract and for cancers of the female genital tract. Conclusions: Results from the Scotland data confirmed the increased risk of total (‘all sites’) cancer previously observed among female burn survivors in Western Australia. The gender dimorphism observed in this study may be related to the role of gender in the immune response to burn injury. More research is required to understand the underlying mechanism(s) that may link burn injury with an increased risk of some cancers.

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      © 2015 Elsevier Ltd. All rights reserved. Background Advances in the treatment and management of burn patients over the past decades have resulted in a decline of in-hospital mortality rates. Current estimates of burn-related ...
    • Long term cardiovascular impacts after burn and non-burn trauma: A comparative population-based study
      Duke, J.; Randall, Sean; Fear, M.; O'Halloran, E.; Boyd, James; Rea, S.; Wood, F. (2017)
      © 2017 Elsevier Ltd and ISBI. Objective: To compare post-injury cardiovascular disease (CVD) hospital admissions experienced by burn patients with non-burn trauma patients and people with no record of injury, adjusting ...
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      Duke, J.; Rea, S.; Boyd, James; Randall, S.; Wood, F. (2015)
      OBJECTIVE: To assess the impact of burn injury sustained during childhood on long-term abstract mortality and to quantify any increased risk of death attributable to burn injury. METHODS: A population-based cohort study ...
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