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    Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images

    189936_189936.pdf (408.1Kb)
    Access Status
    Open access
    Authors
    Chaichana, Thanapong
    Sun, Zhonghua
    Jewkes, James
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Chaichana, Thanapong and Sun, Zhonghua and Jewkes, James. 2012. Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images. Australasian Physical & Engineering Science in Medicine. 35: pp. 231-236.
    Source Title
    Australasian Physical & Engineering Science in Medicine
    DOI
    10.1007/s13246-012-0135-3
    ISSN
    0158-9938
    URI
    http://hdl.handle.net/20.500.11937/26711
    Collection
    • Curtin Research Publications
    Abstract

    The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left anterior descending and left circumflex branches with more than 50 % lumen narrowing. Computational fluid dynamics analysis was used to perform simulation of patient-specific models with realistic physiological conditions that demonstrate in vivo cardiac flow. WSS and blood flow in the LCA were measured during cardiac cycles. Our results showed that WSS was found to increase at the stenotic locations and decrease at pre- and post-plaque locations, whilst the recirculation location was found at post-plaque regions. There is a strong correlation between coronary bifurcation plaques and hemodynamic and WSS changes, based on the realistic coronary disease models.

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