Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations
MetadataShow full item record
The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface l-leucine concentration is necessary to achieve optimal surface and bulk powder properties. Polyvinylpyrrolidone was spray dried with different concentration of l-leucine and the change in surface composition of the formulations was determined using X-ray photoelectron spectroscopy (XPS) and time of flight-secondary ion mass spectrometry (ToF-SIMS). The formulations were also subjected to powder X-ray diffraction analysis in order to understand the relationship between surface concentration and solid-state properties of l-leucine. In addition, the morphology, surface energy and bulk cohesion of spray dried formulations were also assessed to understand the relation between surface l-leucine concentration and surface and bulk properties. The surface concentration of l-leucine increased with higher feed concentrations and plateaued at about 10% l-leucine. Higher surface l-leucine concentration also resulted in the formation of larger l-leucine crystals and not much change in crystal size was noted above 10% l-leucine. A change in surface morphology of particles from spherical to increasingly corrugated was also observed with increasing surface l-leucine concentration. Specific collapsed/folded over particles were only seen in formulations with 10% or higher l-leucine feed concentration suggesting a change in particle surface formation process. In addition, bulk cohesion also reduced and approached a minimum with 10% l-leucine concentration. Thus, the surface concentration of l-leucine governs particle formation and optimum surface l-leucine concentration results in optimum surface and bulk powder properties.
Showing items related by title, author, creator and subject.
Effect of addition of whey protein isolate on spray-drying behavior of honey with maltodextrin as a carrier materialShi, Q.; Fang, Zhongxiang; Bhandari, B. (2013)The efficiency of two drying carriers, namely whey protein isolate (WPI) and maltodextrin (MD), alone or in combination, was evaluated during spray-drying of honey. No powder was recovered when pure honey was spray-dried. ...
Fang, Zhongxiang; Wang, R.; Bhandari, B. (2013)Dairy proteins (whey protein isolate, hydrolyzed whey protein, calcium-caseinate, and hydrolyzed caseinate) and plant proteins (soy protein isolate, pea protein isolate, and rice protein concentrate) were used to spray-dry ...
Che Ibrahim, Shariff (2010)Barley straw, an agricultural byproduct, was identified as a potential adsorbent material for wastewater treatment as it offers various advantages such as abundant availability at no or very low cost, little processing ...