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    Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations

    Access Status
    Fulltext not available
    Authors
    Mangal, S.
    Meiser, F.
    Tan, G.
    Gengenbach, T.
    Denman, J.
    Rowles, Matthew
    Larson, I.
    Morton, D.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Mangal, S. and Meiser, F. and Tan, G. and Gengenbach, T. and Denman, J. and Rowles, M. and Larson, I. et al. 2015. Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations. European Journal of Pharmaceutics and Biopharmaceutics. 94: pp. 160-169.
    Source Title
    European Journal of Pharmaceutics and Biopharmaceutics
    DOI
    10.1016/j.ejpb.2015.04.035
    ISSN
    0939-6411
    School
    Department of Physics and Astronomy
    URI
    http://hdl.handle.net/20.500.11937/2700
    Collection
    • Curtin Research Publications
    Abstract

    The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface l-leucine concentration is necessary to achieve optimal surface and bulk powder properties. Polyvinylpyrrolidone was spray dried with different concentration of l-leucine and the change in surface composition of the formulations was determined using X-ray photoelectron spectroscopy (XPS) and time of flight-secondary ion mass spectrometry (ToF-SIMS). The formulations were also subjected to powder X-ray diffraction analysis in order to understand the relationship between surface concentration and solid-state properties of l-leucine. In addition, the morphology, surface energy and bulk cohesion of spray dried formulations were also assessed to understand the relation between surface l-leucine concentration and surface and bulk properties. The surface concentration of l-leucine increased with higher feed concentrations and plateaued at about 10% l-leucine. Higher surface l-leucine concentration also resulted in the formation of larger l-leucine crystals and not much change in crystal size was noted above 10% l-leucine. A change in surface morphology of particles from spherical to increasingly corrugated was also observed with increasing surface l-leucine concentration. Specific collapsed/folded over particles were only seen in formulations with 10% or higher l-leucine feed concentration suggesting a change in particle surface formation process. In addition, bulk cohesion also reduced and approached a minimum with 10% l-leucine concentration. Thus, the surface concentration of l-leucine governs particle formation and optimum surface l-leucine concentration results in optimum surface and bulk powder properties.

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