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dc.contributor.authorMangal, S.
dc.contributor.authorMeiser, F.
dc.contributor.authorTan, G.
dc.contributor.authorGengenbach, T.
dc.contributor.authorDenman, J.
dc.contributor.authorRowles, Matthew
dc.contributor.authorLarson, I.
dc.contributor.authorMorton, D.
dc.date.accessioned2017-01-30T10:25:16Z
dc.date.available2017-01-30T10:25:16Z
dc.date.created2016-01-20T20:00:33Z
dc.date.issued2015
dc.identifier.citationMangal, S. and Meiser, F. and Tan, G. and Gengenbach, T. and Denman, J. and Rowles, M. and Larson, I. et al. 2015. Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations. European Journal of Pharmaceutics and Biopharmaceutics. 94: pp. 160-169.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/2700
dc.identifier.doi10.1016/j.ejpb.2015.04.035
dc.description.abstract

The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface l-leucine concentration is necessary to achieve optimal surface and bulk powder properties. Polyvinylpyrrolidone was spray dried with different concentration of l-leucine and the change in surface composition of the formulations was determined using X-ray photoelectron spectroscopy (XPS) and time of flight-secondary ion mass spectrometry (ToF-SIMS). The formulations were also subjected to powder X-ray diffraction analysis in order to understand the relationship between surface concentration and solid-state properties of l-leucine. In addition, the morphology, surface energy and bulk cohesion of spray dried formulations were also assessed to understand the relation between surface l-leucine concentration and surface and bulk properties. The surface concentration of l-leucine increased with higher feed concentrations and plateaued at about 10% l-leucine. Higher surface l-leucine concentration also resulted in the formation of larger l-leucine crystals and not much change in crystal size was noted above 10% l-leucine. A change in surface morphology of particles from spherical to increasingly corrugated was also observed with increasing surface l-leucine concentration. Specific collapsed/folded over particles were only seen in formulations with 10% or higher l-leucine feed concentration suggesting a change in particle surface formation process. In addition, bulk cohesion also reduced and approached a minimum with 10% l-leucine concentration. Thus, the surface concentration of l-leucine governs particle formation and optimum surface l-leucine concentration results in optimum surface and bulk powder properties.

dc.subject- Inter-particle cohesion
dc.subject- Spray drying
dc.subjectL-Leucine
dc.subject- Polyvinylpyrrolidone
dc.subject- Surface mapping
dc.titleRelationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations
dc.typeJournal Article
dcterms.source.volume94
dcterms.source.startPage160
dcterms.source.endPage169
dcterms.source.issn0939-6411
dcterms.source.titleEuropean Journal of Pharmaceutics and Biopharmaceutics
curtin.departmentDepartment of Physics and Astronomy
curtin.accessStatusFulltext not available


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