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dc.contributor.authorMangal, S.
dc.contributor.authorMeiser, F.
dc.contributor.authorTan, G.
dc.contributor.authorGengenbach, T.
dc.contributor.authorDenman, J.
dc.contributor.authorRowles, Matthew
dc.contributor.authorLarson, I.
dc.contributor.authorMorton, D.
dc.identifier.citationMangal, S. and Meiser, F. and Tan, G. and Gengenbach, T. and Denman, J. and Rowles, M. and Larson, I. et al. 2015. Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations. European Journal of Pharmaceutics and Biopharmaceutics. 94: pp. 160-169.

The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It was hypothesized that optimum surface l-leucine concentration is necessary to achieve optimal surface and bulk powder properties. Polyvinylpyrrolidone was spray dried with different concentration of l-leucine and the change in surface composition of the formulations was determined using X-ray photoelectron spectroscopy (XPS) and time of flight-secondary ion mass spectrometry (ToF-SIMS). The formulations were also subjected to powder X-ray diffraction analysis in order to understand the relationship between surface concentration and solid-state properties of l-leucine. In addition, the morphology, surface energy and bulk cohesion of spray dried formulations were also assessed to understand the relation between surface l-leucine concentration and surface and bulk properties. The surface concentration of l-leucine increased with higher feed concentrations and plateaued at about 10% l-leucine. Higher surface l-leucine concentration also resulted in the formation of larger l-leucine crystals and not much change in crystal size was noted above 10% l-leucine. A change in surface morphology of particles from spherical to increasingly corrugated was also observed with increasing surface l-leucine concentration. Specific collapsed/folded over particles were only seen in formulations with 10% or higher l-leucine feed concentration suggesting a change in particle surface formation process. In addition, bulk cohesion also reduced and approached a minimum with 10% l-leucine concentration. Thus, the surface concentration of l-leucine governs particle formation and optimum surface l-leucine concentration results in optimum surface and bulk powder properties.

dc.subject- Inter-particle cohesion
dc.subject- Spray drying
dc.subject- Polyvinylpyrrolidone
dc.subject- Surface mapping
dc.titleRelationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations
dc.typeJournal Article
dcterms.source.titleEuropean Journal of Pharmaceutics and Biopharmaceutics
curtin.departmentDepartment of Physics and Astronomy
curtin.accessStatusFulltext not available

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