Guidelines for Reporting Novel mecA Gene Homologues
MetadataShow full item record
Methicillin-resistant staphylococci are disseminated all over the world and are frequent causes of health care- and community-associated infections. Methicillin-resistant strains typically carry the acquired mecA gene that encodes a low-affinity penicillin-binding protein (PBP), designated PBP2a or PBP2′. In most strains, mecA is part of a chromosomally integrated mobile genetic element called staphylococcal cassette chromosome mec (SCCmec). The mecA gene is widely disseminated among Staphylococcus aureus and other staphylococcal species, and its expression is essential for the methicillin-resistant phenotype. Recently, mecA gene homologues that are only distantly related to mecA have been identified in the genomes of staphylococci and some related bacterial species (Table 1). So far, four groups of mecA homologues have been described based on their degree of homology to the earliest identified mecA gene. We believe that this diversity warrants a new naming system based on phylogenetic principles which can also serve as a guideline for the reporting of additional novel mecA homologues that may be identified in the future.
Showing items related by title, author, creator and subject.
PCR assays in detecting methicillin resistance in staphylococci: Coagulase negative staphylococci (CNS), S. aureus, and MRSA with the PVL geneMerlino, J.; Kay, I.; Coombs, Geoffrey; Palladino, S. (2010)Methicillin resistance, in particular hetero-methicillin resistance, in S aureus and the coagulase negative staphylococci (CNS) can be difficult to detect by phenotypic methods. Subsequently detection of the mecA gene for ...
Lim, Tien Tze (2007)Seventy-four methicillin-resistant Staphylococcus aureus (MRSA) from two Malaysian hospitals were characterised by both phenotypic and genotypic techniques. These isolates were collected over an 18 year time period in the ...
A LuxRI-family regulatory system controls excision and transfer of the Mesorhizobium loti strain R7A symbiosis island by activating expression of two conserved hypothetical genesRamsay, Joshua; Sullivan, J.; Jambari, N.; Ortori, C.; Heeb, S.; Williams, P.; Barrett, D.; Lamont, L.; Ronson, C. (2009)The symbiosis island ICEM/SymR7A of Mesorhizobium loti R7A is an integrative and conjugative element (ICE) that carries genes required for a nitrogen-fixing symbiosis with Lotus species. ICEM/SymR7A encodes homologues ...