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    Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system

    Access Status
    Fulltext not available
    Authors
    Meng, Z.
    Xu, X.
    Zheng, W.
    Zhou, H.
    Li, L.
    Zheng, Y.
    Lou, Xia
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Abstract

    Drug (Fenbufen, FBF)-loaded poly(D,L-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking time and pH value of the buffer solution on FBF release behavior of the resulting nanofibrous scaffolds were investigated, with the corresponding FBF-loaded PLGA and PLGA/gelatin solvent-cast films as controls. The release rate of FBF was found to be increased with the increment of gelatin content for all the composite samples, and the FBF release rate of aligned nanofibrous scaffold was lower than that of randomly oriented scaffold. Moreover, the crosslinking treatment depressed effectively the burst release of FBF at initial release stage of PLGA/gelatin (9/1) nanofibrous scaffold. In addition, the pH value of the buffer solution could change the physical state of the polymer and affect the FBF release rate.

    Citation
    Meng, Z.X. and Xu, X.X. and Zheng, W. and Zhou, H.M. and Li, L. and Zheng, Y.F. and Lou, X. 2011. Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system. Colloids and Surfaces B: Biointerfaces. 84: pp. 97-102.
    Source Title
    Colloids and Surfaces B: Biointerfaces
    DOI
    10.1016/j.colsurfb.2010.12.022
    ISSN
    18734367
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/30184
    Collection
    • Curtin Research Publications

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