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dc.contributor.authorPeters, S.
dc.contributor.authorHuxley, Rachel
dc.contributor.authorWoodward, M.
dc.date.accessioned2017-01-30T12:59:32Z
dc.date.available2017-01-30T12:59:32Z
dc.date.created2016-02-04T19:30:29Z
dc.date.issued2013
dc.identifier.citationPeters, S. and Huxley, R. and Woodward, M. 2013. Smoking as a risk factor for stroke in women compared with men: A systematic review and meta-analysis of 81 cohorts, including 3 980 359 individuals and 42 401 strokes. Stroke. 44 (10): pp. 2821-2828.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/27535
dc.identifier.doi10.1161/STROKEAHA.113.002342
dc.description.abstract

Background and Purpose-It is currently unknown whether the excess risk of stroke by smoking is the same for women and men. We performed a systematic review and meta-analysis to estimate the effect of smoking on stroke in women compared with men. Methods-PubMed MEDLINE was systematically searched for prospective population-based cohort studies published between January 1, 1966, and January 26, 2013. Studies that presented sex-specific estimates of the relative risk of stroke comparing current smoking with nonsmoking and its associated variability were selected. The sex-specific relative risks and their ratio (RRR), comparing women with men, were pooled using random-effects meta-analysis with inverse variance weighting. Similarly, the RRR for former versus never smoking was pooled. Results-Data from 81 prospective cohort studies that included 3 980 359 individuals and 42 401 strokes were available. Smoking was an independent risk factor for stroke in both sexes. Overall, the pooled multiple-adjusted RRR indicated a similar risk of stroke associated with smoking in women compared with men (RRR, 1.06 [95% confidence interval, 0.99-1.13]). In a regional analysis, there was evidence of a more harmful effect of smoking in women than in men in Western (RRR, 1.10 [1.02-1.18)] but not in Asian (RRR, 0.97 [0.87-1.09]) populations. Compared with never-smokers, the beneficial effects of quitting smoking among former smokers on stroke risk were similar between the sexes (RRR, 1.10 [0.99-1.22]). Conclusions-Compared with nonsmokers, the excess risk of stroke is at least as great among women who smoke compared with men who smoke. © 2013 American Heart Association, Inc.

dc.titleSmoking as a risk factor for stroke in women compared with men: A systematic review and meta-analysis of 81 cohorts, including 3 980 359 individuals and 42 401 strokes
dc.typeJournal Article
dcterms.source.volume44
dcterms.source.number10
dcterms.source.startPage2821
dcterms.source.endPage2828
dcterms.source.issn0039-2499
dcterms.source.titleStroke
curtin.departmentSchool of Public Health
curtin.accessStatusOpen access via publisher


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