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    Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: A prospective cohort study from ADVANCE

    Access Status
    Fulltext not available
    Authors
    Czernichow, S.
    Kengne, A.
    Huxley, Rachel
    Batty, G.
    De Galan, B.
    Grobbee, D.
    Pillai, A.
    Zoungas, S.
    Marre, M.
    Woodward, M.
    Neal, B.
    Chalmers, J.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Czernichow, S. and Kengne, A. and Huxley, R. and Batty, G. and De Galan, B. and Grobbee, D. and Pillai, A. et al. 2011. Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: A prospective cohort study from ADVANCE. European Journal of Cardiovascular Prevention and Rehabilitation. 18 (2): pp. 312-319.
    Source Title
    European Journal of Cardiovascular Prevention and Rehabilitation
    DOI
    10.1097/HJR.0b013e32833c1aa3
    ISSN
    1741-8267
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/27732
    Collection
    • Curtin Research Publications
    Abstract

    Aims: The aim of this study was to compare the strength of associations and discrimination capability of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) with cardiovascular disease risk in individuals with type-2 diabetes. Methods and results: Eleven thousand, one hundred and forty men and women were followed for a mean of 4.8 years. The Cox proportional hazard models were used to compute the hazard ratios and 95% confidence intervals (95% CI) for one standard deviation (SD) increase in baseline BMI (SD: 5kg/m2), WC (SD: 13cm) and WHR (SD: 0.08) with cardiovascular disease risk. After adjustment, hazard ratio (95% CI) for WC were 1.10 (1.03-1.18) for cardiovascular events, 1.13 (1.03-1.24) for coronary events, and 1.08 (0.98-1.19) for cardiovascular deaths. Estimates for WHR were 1.12 (1.05-1.19), 1.17 (1.08-1.28) and 1.19 (1.09-1.31). BMI was not related to any of these outcomes. Although the receiver operating characteristic curve could not differentiate between anthropometric variables (P values = 0.24), the relative integrated discrimination improvement statistic showed an enhancement in the discrimination capabilities of models using WHR for cardiovascular outcomes, except for cerebrovascular events. Conclusion: Strengths of associations and discrimination statistics suggested that WHR was the best predictor of cardiovascular events and mortality in patients with type-2 diabetes and BMI the worst. © The European Society of Cardiology 2011.

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