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    Pharmacokinetics of dihydroartemisinin in a murine malaria model

    Access Status
    Fulltext not available
    Authors
    Batty, Kevin
    Gibbons, Peter
    Davis, Timothy
    Ilett, K.
    Date
    2008
    Type
    Journal Article
    
    Metadata
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    Citation
    Batty, Kevin T. and Gibbons, Peter L. and Davis, Timothy M. E. and Ilett, Kenneth F. 2008. Pharmacokinetics of dihydroartemisinin in a murine malaria model. American Journal of Tropical Medicine and Hygiene 78 (4): pp. 641-642.
    Source Title
    American Journal of Tropical Medicine and Hygiene
    ISSN
    00029637
    Faculty
    Faculty of Health Sciences
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/27968
    Collection
    • Curtin Research Publications
    Abstract

    Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic–pharmacodynamic evaluations of DHA in murine models.

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