Pharmacokinetics of dihydroartemisinin in a murine malaria model
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Authors
Batty, Kevin
Gibbons, Peter
Davis, Timothy
Ilett, K.
Date
2008Type
Journal Article
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Batty, Kevin T. and Gibbons, Peter L. and Davis, Timothy M. E. and Ilett, Kenneth F. 2008. Pharmacokinetics of dihydroartemisinin in a murine malaria model. American Journal of Tropical Medicine and Hygiene 78 (4): pp. 641-642.
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American Journal of Tropical Medicine and Hygiene
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Faculty
Faculty of Health Sciences
School of Pharmacy
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Abstract
Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic–pharmacodynamic evaluations of DHA in murine models.