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dc.contributor.authorLiu, Lihong
dc.contributor.authorVenkatraman, S.
dc.contributor.authorYang, Y.
dc.contributor.authorGuo, K.
dc.contributor.authorLu, J.
dc.contributor.authorHe, B.
dc.contributor.authorMoochhala, S.
dc.contributor.authorKan, L.
dc.date.accessioned2017-01-30T13:04:20Z
dc.date.available2017-01-30T13:04:20Z
dc.date.created2016-09-12T08:36:37Z
dc.date.issued2008
dc.identifier.citationLiu, L. and Venkatraman, S. and Yang, Y. and Guo, K. and Lu, J. and He, B. and Moochhala, S. et al. 2008. Polymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier, pp. 617-623.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/28321
dc.identifier.doi10.1002/bip.20998
dc.description.abstract

Polymeric micelles self-assembled from cholesterol-conjugated poly(ethylene glycol) (PEG) and anchored with transcriptional activator TAT peptide (TAT-PEG-b-Col) were fabricated for delivery of antibiotics across the blood-brain barrier (BBB). Ciprofloxacin, which demonstrated a high bactericidal effect, was efficiently loaded into the micelles by a membrane dialysis method. The ciprofloxacin-loaded micelles were characterized via dynamic light scattering and SEM. The micelles were spherical in nature, having an average diameter of smaller than 180 nm. Sustained release of ciprofloxacin was achieved over 6 h in phosphate-buffered saline (pH 7.4) at 37°C. Confocal laser scanning microscopy reveals that the uptake of Fluorescein 5-isothiocyanate (FITC)-loaded TAT-PEG-b-Col micelles by human astrocytes was much higher than that of free FITC. Animal studies proved that these micelles crossed the BBB and entered the brain. The TAT-conjugated micelles may be used to deliver antibiotics across the BBB for treatment of brain infections. © 2008 Wiley Periodicals, Inc.

dc.titlePolymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier
dc.typeConference Paper
dcterms.source.volume90
dcterms.source.startPage617
dcterms.source.endPage623
dcterms.source.issn0006-3525
dcterms.source.titleBiopolymers - Peptide Science Section
dcterms.source.seriesBiopolymers - Peptide Science Section
curtin.departmentDepartment of Chemical Engineering
curtin.accessStatusFulltext not available


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