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dc.contributor.authorLim, Felicia Phei Lin
dc.contributor.authorDolzhenko, Anton
dc.date.accessioned2017-01-30T13:05:20Z
dc.date.available2017-01-30T13:05:20Z
dc.date.created2014-08-12T20:00:23Z
dc.date.issued2014
dc.identifier.citationLim, F.P.L. and Dolzhenko, A. 2014. 1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry. European Journal of Medicinal Chemistry. 85: pp. 371-390.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/28486
dc.identifier.doi10.1016/j.ejmech.2014.07.112
dc.description.abstract

Purines can be considered as the most ubiquitous and functional N-heterocyclic compounds in nature. Structural modifications of natural purines, particularly using isosteric ring systems, have been in the focus of many drug discovery programs. Fusion of 1,3,5-triazine ring with pyrrole, pyrazole, imidazole, 1,2,3-triazole or 1,2,4-triazole results in seven bicyclic heterocyclic systems isosteric to purine. Application of the isosterism concept for the development of new compounds with therapeutic potential in areas involving purinergic regulation or purine metabolism led to significant advances in medicinal chemistry of the azolo[1,3,5]triazines. These 1,3,5-triazine-based purine-like scaffolds significantly increase level of molecular diversity and allow covering chemical space in the important areas of medicinal chemistry. Some of these azolo[1,3,5]triazine systems have become privileged scaffolds in the development of inhibitors of various kinases, phosphodiesterase, xanthine oxidase, and thymidine phosphorylase, antagonists of adenosine and corticotropin-releasing hormone receptors, anticancer and antiviral agents.

dc.publisherElsevier Masson
dc.subjectPurine
dc.subjectAntiviral
dc.subjectAnticancer
dc.subjectTriazine
dc.subjectIsostere
dc.subjectEnzyme inhibitor
dc.title1,3,5-Triazine-based analogues of purine: From isosteres to privileged scaffolds in medicinal chemistry
dc.typeJournal Article
dcterms.source.volume85
dcterms.source.startPage371
dcterms.source.endPage390
dcterms.source.issn0223-5234
dcterms.source.titleEuropean Journal of Medicinal Chemistry
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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