Atherosclerosis and Atheroma Plaque Rupture: Normal Anatomy of Vasa Vasorum and Their Role Associated with Atherosclerosis
MetadataShow full item record
Atherosclerosis is primarily a degenerative disorder related to aging with a chronic inflammatory component. There are differences in expression among different vascular beds, inflicting a range of vascular diseases. The majority of studies focus on the inner and medial vascular layers, which are affected at the development of atherosclerosis. Recent evidence shows that the outer layer of blood vessels, composed of the adventitial layer and the vasa vasorum, not only plays a significant role in maintaining vessel integrity, but also reacts to atheroma. What is not clear is the extent of contribution of the outer layer to the process of atherosclerosis. Is it involved in the initiation, progression, and clinical expression of atheroma? Is the inflammation associated with atheroma limited to being merely reactive or is there a proactive element? This paper provides an overview of the normal anatomy of vasa vasorum and potential mechanism of plaque formation due to vascular injury (vasa vasorum) and microhemorrhage.
This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.
Showing items related by title, author, creator and subject.
Disease trends over time and CD4<sup>+</sup>CCR5<sup>+</sup>T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosusBaragetti, A.; Ramirez, G.; Magnoni, M.; Garlaschelli, K.; Grigore, L.; Berteotti, M.; Scotti, I.; Bozzolo, E.; Berti, A.; Camici, P.; Catapano, A.; Manfredi, A.; Ammirati, E.; Norata, Giuseppe (2017)© 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Background ...
Norata, Giuseppe; Venu, V.; Callegari, E.; Paloschi, V.; Catapano, A. (2012)The reduced expression (haplodeficiency) of the main brain derived neurotrophic factor receptor, namely TrkB is associated with reduced atherosclerosis, smooth muscle cells accumulation and collagen content in the lesion. ...
Ne, J.; Cai, T.; Celermajer, D.; Caterson, I.; Gill, T.; Lee, Crystal; Skilton, M. (2017)Objective: Obesity is an established risk factor for cardiovascular disease. The mechanisms by which obesity affects cardiovascular risk have not been fully elucidated. This paper reports a comprehensive systematic review ...