Obesity, arterial function and arterial structure - a systematic review and meta-analysis
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Objective: Obesity is an established risk factor for cardiovascular disease. The mechanisms by which obesity affects cardiovascular risk have not been fully elucidated. This paper reports a comprehensive systematic review and meta-analysis on obesity and two key aspects of vascular health using gold-standard non-invasive measures - arterial endothelial function (brachial flow-mediated dilatation) and subclinical atherosclerosis (carotid intima-media thickness). Methods: Electronic searches for 'Obesity and flow-mediated dilatation' and 'Obesity and intima-media thickness' were performed using Ovid Medline and Embase databases. A meta-analysis was undertaken for brachial flow-mediated dilatation and carotid intima-media thickness to obtain pooled estimates for adults with obesity and those with healthy weight. Results: Of the 5,810 articles retrieved, 19 studies on flow-mediated dilatation and 19 studies on intima-media thickness were included. Meta-analysis demonstrated that obesity was associated with lower flow-mediated dilatation (-1.92 % [95% CI -2.92, -0.92], P = 0.0002) and greater carotid intima-media thickness (0.07 mm [95% CI 0.05, 0.08], P < 0.0001). Conclusions: Obesity is associated with poorer arterial endothelial function and increased subclinical atherosclerosis, consistent with these aspects of vascular health at least partially contributing to the increased risk of cardiovascular events in adults with obesity. These estimated effect sizes will enable vascular health benefits in response to weight loss treatment to be put in greater perspective, both in the research setting and potentially also clinical practice.
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Skilton, M.; Yeo, S.; Ne, J.; Celermajer, D.; Caterson, I.; Lee, Crystal (2017)Objective: Obesity is a risk factor for clinical cardiovascular disease, putatively via increased burden of atherosclerosis. It remains contentious as to whether weight loss in people with obesity is accompanied by a ...
Carotid Intima-Media thickness progression and risk of vascular events in people with Diabetes: Results from the PROG-IMT collaborationLorenz, M.; Price, J.; Robertson, C.; Bots, M.; Polak, J.; Poppert, H.; Kavousi, M.; Dorr, M.; Stensland, E.; Ducimetiere, P.; Ronkainen, K.; Kiechl, S.; Sitzer, M.; Rundek, T.; Lind, L.; Liu, J.; Bergstrom, G.; Grigore, L.; Bokemark, L.; Friera, A.; Yanez, D.; Bickel, H.; Ikram, M.; Volzke, H.; Johnsen, S.; Empana, J.; Tuomainen, T.; Willeit, P.; Steinmetz, H.; Desvarieux, M.; Xie, W.; Schmidt, C.; Norata, Giuseppe; Suarez, C.; Sander, D.; Hofman, A.; Schminke, U.; Mathiesen, E.; Plichart, M.; Kauhanen, J.; Willeit, J.; Sacco, R.; McLachlan, S.; Zhao, D.; Fagerberg, B.; Catapano, A.; Gabriel, R.; Franco, O.; Bulbul, A.; Scheckenbach, F.; Pflug, A.; Gao, L.; Thompson, S. (2015)© 2015 by the American Diabetes Association. OBJECTIVE Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also ...
Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal VariantBoardman-Pretty, F.; Smith, A.; Cooper, J.; Palmen, J.; Folkersen, L.; Hamsten, A.; Catapano, A.; Melander, O.; Price, J.; Kumari, M.; Deanfield, J.; Kivimäki, M.; Gertow, K.; Baragetti, A.; Norata, Giuseppe; Humphries, S. (2015)© 2015 American Heart Association, Inc. Background-Carotid intima-media thickness (IMT) is a marker of subclinical atherosclerosis that can predict cardiovascular disease events over traditional risk factors. This study ...