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Hemodynamic impacts of various types of stenosis in the left coronary artery bifurcation: A patient-specific analysis

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Authors
Chaichana, Thanapong
Sun, Zhonghua
Jewkes, James
Date
2013
Type
Journal Article

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Chaichana, Thanapong and Sun, Zhonghua and Jewkes, James. 2013. Hemodynamic impacts of various types of stenosis in the left coronary artery bifurcation: A patient-specific analysis. Physica Medica. 29 (5): pp. 447-452.
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Physica Medica
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NOTICE: this is the author’s version of a work that was accepted for publication in Physica Medica. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Physica Medica, Vol. 29 (2013). DOI: 10.1016/j.ejmp.2013.02.001

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Abstract

This study investigates the hemodynamic changes to various types of coronary stenosis in the left coronary artery bifurcation, based on a patient-specific analysis. Twenty two patients with left coronary artery disease were included in this study. All stenoses involving the left coronary artery bifurcation were classified into four types, according to their locations: A) left circumflex (LCx) and left anterior descending (LAD), B) LCx only, C) left main stem only, and D) LAD only. Computational fluid dynamics (CFD) was performed to analyze the flow and wall shear stress (WSS) changes in all reconstructed left coronary geometries. Our results showed that the flow velocity and WSS were significantly increased at stenotic locations. High WSS was found at >70% lumen stenosis, which ranged from 2.5 Pa to 3.5 Pa. This study demonstrates that in patients with more than 50% stenosis in the left coronary artery bifurcation, WSS plays an important role in providing information about the extent of coronary atherosclerosis in the left coronary artery branch.