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    Cubyl amides: Novel P2X7 receptor antagonists

    Access Status
    Fulltext not available
    Authors
    Gunosewoyo, Hendra
    Guo, J.
    Bennett, M.
    Coster, M.
    Kassiou, M.
    Date
    2008
    Type
    Journal Article
    
    Metadata
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    Citation
    Gunosewoyo, Hendra and Guo, Jun Liu and Bennett, Maxwell R. and Coster, Mark J. and Kassiou, Michael. 2008. Cubyl amides: Novel P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 18 (13): pp. 3720-3723.
    Source Title
    Bioorganic & Medicinal Chemistry Letters
    DOI
    10.1016/j.bmcl.2008.05.062
    ISSN
    0960-894X
    URI
    http://hdl.handle.net/20.500.11937/29736
    Collection
    • Curtin Research Publications
    Abstract

    Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.

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