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dc.contributor.authorGunosewoyo, Hendra
dc.contributor.authorGuo, J.
dc.contributor.authorBennett, M.
dc.contributor.authorCoster, M.
dc.contributor.authorKassiou, M.
dc.date.accessioned2017-01-30T13:14:48Z
dc.date.available2017-01-30T13:14:48Z
dc.date.created2014-02-18T20:00:21Z
dc.date.issued2008
dc.identifier.citationGunosewoyo, Hendra and Guo, Jun Liu and Bennett, Maxwell R. and Coster, Mark J. and Kassiou, Michael. 2008. Cubyl amides: Novel P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 18 (13): pp. 3720-3723.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/29736
dc.identifier.doi10.1016/j.bmcl.2008.05.062
dc.description.abstract

Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.

dc.publisherPergamon
dc.subjectPolycyclic benzamides
dc.subjectP2X7 antagonists
dc.subjectMicroglia
dc.subjectRational drug design
dc.titleCubyl amides: Novel P2X7 receptor antagonists
dc.typeJournal Article
dcterms.source.volume18
dcterms.source.startPage3720
dcterms.source.endPage3723
dcterms.source.issn0960-894X
dcterms.source.titleBioorganic & Medicinal Chemistry Letters
curtin.department
curtin.accessStatusFulltext not available


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