Cubyl amides: Novel P2X7 receptor antagonists
| dc.contributor.author | Gunosewoyo, Hendra | |
| dc.contributor.author | Guo, J. | |
| dc.contributor.author | Bennett, M. | |
| dc.contributor.author | Coster, M. | |
| dc.contributor.author | Kassiou, M. | |
| dc.date.accessioned | 2017-01-30T13:14:48Z | |
| dc.date.available | 2017-01-30T13:14:48Z | |
| dc.date.created | 2014-02-18T20:00:21Z | |
| dc.date.issued | 2008 | |
| dc.identifier.citation | Gunosewoyo, Hendra and Guo, Jun Liu and Bennett, Maxwell R. and Coster, Mark J. and Kassiou, Michael. 2008. Cubyl amides: Novel P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 18 (13): pp. 3720-3723. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/29736 | |
| dc.identifier.doi | 10.1016/j.bmcl.2008.05.062 | |
| dc.description.abstract |
Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity. | |
| dc.publisher | Pergamon | |
| dc.subject | Polycyclic benzamides | |
| dc.subject | P2X7 antagonists | |
| dc.subject | Microglia | |
| dc.subject | Rational drug design | |
| dc.title | Cubyl amides: Novel P2X7 receptor antagonists | |
| dc.type | Journal Article | |
| dcterms.source.volume | 18 | |
| dcterms.source.startPage | 3720 | |
| dcterms.source.endPage | 3723 | |
| dcterms.source.issn | 0960-894X | |
| dcterms.source.title | Bioorganic & Medicinal Chemistry Letters | |
| curtin.department | ||
| curtin.accessStatus | Fulltext not available |