Show simple item record

dc.contributor.authorKent, J.
dc.contributor.authorGöring, H.
dc.contributor.authorCharlesworth, J.
dc.contributor.authorDrigalenko, E.
dc.contributor.authorDiego, V.
dc.contributor.authorCurran, J.
dc.contributor.authorJohnson, M.
dc.contributor.authorDyer, T.
dc.contributor.authorCole, S.
dc.contributor.authorJowett, J.
dc.contributor.authorMahaney, M.
dc.contributor.authorComuzzie, A.
dc.contributor.authorAlmasy, L.
dc.contributor.authorMoses, Eric
dc.contributor.authorBlangero, J.
dc.contributor.authorWilliams-Blangero, S.
dc.date.accessioned2017-01-30T10:27:43Z
dc.date.available2017-01-30T10:27:43Z
dc.date.created2016-01-20T20:00:34Z
dc.date.issued2012
dc.identifier.citationKent, J. and Göring, H. and Charlesworth, J. and Drigalenko, E. and Diego, V. and Curran, J. and Johnson, M. et al. 2012. Genotype × age interaction in human transcriptional ageing. Mechanisms of Ageing and Development. 133 (9-10): pp. 581-590.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/2992
dc.identifier.doi10.1016/j.mad.2012.07.005
dc.description.abstract

Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood mononuclear cells from 1240 individuals in large families and found 4472 human autosomal transcripts, representing ~4349 genes, significantly correlated with age. We identified 623 transcripts that show genotype by age interaction in addition to a main effect of age, defining a large set of novel candidates for characterization of the mechanisms of differential biological ageing. We applied a novel SNP genotype × age interaction test to one of these candidates, the ubiquilin-like gene UBQLNL, and found evidence of joint cis-association and genotype by age interaction as well as trans-genotype by age interaction for UBQLNL expression. Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort.

dc.titleGenotype × age interaction in human transcriptional ageing
dc.typeJournal Article
dcterms.source.volume133
dcterms.source.number9-10
dcterms.source.startPage581
dcterms.source.endPage590
dcterms.source.issn0047-6374
dcterms.source.titleMechanisms of Ageing and Development
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record