Genotype × age interaction in human transcriptional ageing
dc.contributor.author | Kent, J. | |
dc.contributor.author | Göring, H. | |
dc.contributor.author | Charlesworth, J. | |
dc.contributor.author | Drigalenko, E. | |
dc.contributor.author | Diego, V. | |
dc.contributor.author | Curran, J. | |
dc.contributor.author | Johnson, M. | |
dc.contributor.author | Dyer, T. | |
dc.contributor.author | Cole, S. | |
dc.contributor.author | Jowett, J. | |
dc.contributor.author | Mahaney, M. | |
dc.contributor.author | Comuzzie, A. | |
dc.contributor.author | Almasy, L. | |
dc.contributor.author | Moses, Eric | |
dc.contributor.author | Blangero, J. | |
dc.contributor.author | Williams-Blangero, S. | |
dc.date.accessioned | 2017-01-30T10:27:43Z | |
dc.date.available | 2017-01-30T10:27:43Z | |
dc.date.created | 2016-01-20T20:00:34Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Kent, J. and Göring, H. and Charlesworth, J. and Drigalenko, E. and Diego, V. and Curran, J. and Johnson, M. et al. 2012. Genotype × age interaction in human transcriptional ageing. Mechanisms of Ageing and Development. 133 (9-10): pp. 581-590. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/2992 | |
dc.identifier.doi | 10.1016/j.mad.2012.07.005 | |
dc.description.abstract |
Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood mononuclear cells from 1240 individuals in large families and found 4472 human autosomal transcripts, representing ~4349 genes, significantly correlated with age. We identified 623 transcripts that show genotype by age interaction in addition to a main effect of age, defining a large set of novel candidates for characterization of the mechanisms of differential biological ageing. We applied a novel SNP genotype × age interaction test to one of these candidates, the ubiquilin-like gene UBQLNL, and found evidence of joint cis-association and genotype by age interaction as well as trans-genotype by age interaction for UBQLNL expression. Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort. | |
dc.title | Genotype × age interaction in human transcriptional ageing | |
dc.type | Journal Article | |
dcterms.source.volume | 133 | |
dcterms.source.number | 9-10 | |
dcterms.source.startPage | 581 | |
dcterms.source.endPage | 590 | |
dcterms.source.issn | 0047-6374 | |
dcterms.source.title | Mechanisms of Ageing and Development | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Fulltext not available |
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