Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Synthesis and bioactivity of gelatin/multiwalled carbon nanotubes/hydroxyapatite nanofibrous scaffolds towards bone tissue engineering

    Access Status
    Fulltext not available
    Authors
    Wang, H.
    Chu, C.
    Cai, R.
    Jiang, S.
    Zhai, L.
    Lu, J.
    Li, Xingjiang
    Jiang, S.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Wang, H. and Chu, C. and Cai, R. and Jiang, S. and Zhai, L. and Lu, J. and Li, X. et al. 2015. Synthesis and bioactivity of gelatin/multiwalled carbon nanotubes/hydroxyapatite nanofibrous scaffolds towards bone tissue engineering. RSC Advances. 5 (66): pp. 53550-53558.
    Source Title
    RSC Advances
    DOI
    10.1039/c5ra07806g
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/30087
    Collection
    • Curtin Research Publications
    Abstract

    The objective of this study was to develop a novel three-dimensional biomimetic gelatin/multiwalled carbon nanotubes/hydroxyapatite (gelatin/MWNTs/HA) nanofibrous scaffold via electrospinning technique for bone tissue engineering. The mechanical properties, structure, morphology and the bioactivity of nanofibrous scaffolds in vitro were investigated. Attentions were focused on the adhesion, mineralization, viability and proliferation of human fetal osteoblastic cells (hFOBs) on scaffold. Resulting scaffolds provided relative good mechanical support (7.9 ± 0.32 MPa) and high porosity (91.2%) to mimic a favorable environment for hFOBs. The hydrogen bonds between gelatin molecules and MWNTs/HA units were confirmed, and the incorporation of HA or MWNTs/HA nanoparticles caused an increase in porosity and strength of scaffolds, meanwhile the surface of nanofibers tended to be rough. HA nanoparticles showed a chelating effect to promote osteogenesis and mineralization of bone, and MWNTs had a synergetic effect with HA to induce the apatite formation. As compared to gelatin and gelatin/HA scaffolds, gelatin/MWNTs/HA scaffold exhibited the best viability hFOB cells cultured in vitro, most excellent morphology of hFOB cells seeded into scaffold and a significantly increasing in proliferation. The nanofibrous scaffold will have great potential as an excellent scaffold for in bone tissue engineering.

    Related items

    Showing items related by title, author, creator and subject.

    • Fabrication and characterisation of electrospun silk fibroin/gelatin scaffolds crosslinked with glutaraldehyde vapour
      Mohammadzademoghadam, Soheila; Dong, Yu (2019)
      Bombyx mori silk fibroin (SF) /gelatin nanofibre mats with different blend ratios of 100/0, 90/10 and 70/30 were prepared by electrospinning and crosslinked with glutaraldehyde (GTA) vapour at room temperature. GTA was ...
    • Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system
      Meng, Z.; Xu, X.; Zheng, W.; Zhou, H.; Li, L.; Zheng, Y.; Lou, Xia (2011)
      Drug (Fenbufen, FBF)-loaded poly(D,L-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking ...
    • Fabrication and Evaluation of Electrospun Silk Fibroin/Halloysite Nanotube Biomaterials for Soft Tissue Regeneration
      Mohammadzadehmoghadam, Soheila; LeGrand, Catherine F; Dong, Yu; Wong, Chee-Wai; Kinnear, Beverley F; Dong, Roger ; Coombe, Deirdre R (2022)
      The production of nanofibrous materials for soft tissue repair that resemble extracellular matrices (ECMs) is challenging. Electrospinning uniquely produces scaffolds resembling the ultrastructure of natural ECMs. Herein, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.