Identification and genetic determination of an early life risk disposition for depressive disorder: Atypical stress-related behaviour in early childhood
MetadataShow full item record
Progress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders. We argue that greater use of early detectable intermediate traits (endophenotypes) with the highest likely aetiological significance to depression, rather than complex clinical phenotypes, would be advantageous. Longitudinal data from the Western Australian Pregnancy Cohort (Raine) Study were used to identify an early life behavioural endophenotype for atypical hypothalamic-pituitary-adrenocortical function in adolescence, a neurobiological indicator of anxiety and depression. A set of descriptors representing rigid and reactive behaviour at age 1 year discriminated those in the top 20% of the free salivary cortisol exposure at age 17 years. Genetic association analysis revealed a male-sensitive effect to variation in three specific single nucleotide polymorphisms within selected genes underpinning the overall stress response. Furthermore, support for a polygenic effect on stress-related behaviour in childhood is presented.
Showing items related by title, author, creator and subject.
Maternal life events during pregnancy and offspring language ability in middle childhood: The Western Australian Pregnancy Cohort StudyWhitehouse, A.; Robinson, M.; Zubrick, Stephen; Ang, Q.; Stanley, F.; Pennell, C e (2010)Maternal life events during pregnancy and offspring language ability in middle childhood: The Western Australian Pregnancy Cohort StudyAndrew J.O. Whitehousea, b, Corresponding Author Contact Information, Monique Robinsona, ...
Brief oral health promotion intervention among parents of young children to reduce early childhood dental decayArrow, P.; Raheb, Joseph; Miller, M. (2013)Background: Severe untreated dental decay affects a child’s growth, body weight, quality of life as well as cognitive development, and the effects extend beyond the child to the family, the community and the health care ...
Loh, Beng Heng (2011)The railway track foundation of fine-grained soil subgrade, under repeated loading of cyclic nature, can gradually build up excess pore pressure and result in progressive shear failure at a stress level much lower than ...