Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Identification and genetic determination of an early life risk disposition for depressive disorder: Atypical stress-related behaviour in early childhood

    Access Status
    Fulltext not available
    Authors
    van Eekelen, A.
    Olssen, C.
    Ellis, J.
    Ang, W.
    Hutchinson, D.
    Zubrick, Stephen
    Pennell, C.
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    van Eekelen, A. and Olssen, C. and Ellis, J. and Ang, W. and Hutchinson, D. and Zubrick, S. and Pennell, C. 2011. Identification and genetic determination of an early life risk disposition for depressive disorder: Atypical stress-related behaviour in early childhood. Australian Journal of Psychology. 63 (1): pp. 6-17.
    Source Title
    Australian Journal of Psychology
    Additional URLs
    http://onlinelibrary.wiley.com/doi/10.1111/j.1742-9536.2011.00002.x/abstract
    ISSN
    00049530
    School
    Centre for Developmental Health (Curtin Research Centre)
    URI
    http://hdl.handle.net/20.500.11937/3018
    Collection
    • Curtin Research Publications
    Abstract

    Progress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders. We argue that greater use of early detectable intermediate traits (endophenotypes) with the highest likely aetiological significance to depression, rather than complex clinical phenotypes, would be advantageous. Longitudinal data from the Western Australian Pregnancy Cohort (Raine) Study were used to identify an early life behavioural endophenotype for atypical hypothalamic-pituitary-adrenocortical function in adolescence, a neurobiological indicator of anxiety and depression. A set of descriptors representing rigid and reactive behaviour at age 1 year discriminated those in the top 20% of the free salivary cortisol exposure at age 17 years. Genetic association analysis revealed a male-sensitive effect to variation in three specific single nucleotide polymorphisms within selected genes underpinning the overall stress response. Furthermore, support for a polygenic effect on stress-related behaviour in childhood is presented.

    Related items

    Showing items related by title, author, creator and subject.

    • Exposure to stressful life events during pregnancy predicts psychotic experiences via behaviour problems in childhood
      Betts, K.; Williams, G.; Najman, J.; Scott, J.; Alati, Rosa (2014)
      © 2014 Elsevier Ltd. All rights reserved. Background: Exposure to stressful life events during pregnancy has been associated with later schizophrenia in offspring. We explore how prenatal stress and neurodevelopmental ...
    • Maternal life events during pregnancy and offspring language ability in middle childhood: The Western Australian Pregnancy Cohort Study
      Whitehouse, A.; Robinson, M.; Zubrick, Stephen; Ang, Q.; Stanley, F.; Pennell, C e (2010)
      Maternal life events during pregnancy and offspring language ability in middle childhood: The Western Australian Pregnancy Cohort StudyAndrew J.O. Whitehousea, b, Corresponding Author Contact Information, Monique Robinsona, ...
    • Brief oral health promotion intervention among parents of young children to reduce early childhood dental decay
      Arrow, P.; Raheb, Joseph; Miller, M. (2013)
      Background: Severe untreated dental decay affects a child’s growth, body weight, quality of life as well as cognitive development, and the effects extend beyond the child to the family, the community and the health care ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.