Show simple item record

dc.contributor.authorvan Eekelen, A.
dc.contributor.authorOlssen, C.
dc.contributor.authorEllis, J.
dc.contributor.authorAng, W.
dc.contributor.authorHutchinson, D.
dc.contributor.authorZubrick, Stephen
dc.contributor.authorPennell, C.
dc.date.accessioned2017-01-30T10:27:49Z
dc.date.available2017-01-30T10:27:49Z
dc.date.created2014-10-08T06:00:36Z
dc.date.issued2011
dc.identifier.citationvan Eekelen, A. and Olssen, C. and Ellis, J. and Ang, W. and Hutchinson, D. and Zubrick, S. and Pennell, C. 2011. Identification and genetic determination of an early life risk disposition for depressive disorder: Atypical stress-related behaviour in early childhood. Australian Journal of Psychology. 63 (1): pp. 6-17.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/3018
dc.description.abstract

Progress in psychiatric genetics has been slow despite evidence of high heritability for most mental disorders. We argue that greater use of early detectable intermediate traits (endophenotypes) with the highest likely aetiological significance to depression, rather than complex clinical phenotypes, would be advantageous. Longitudinal data from the Western Australian Pregnancy Cohort (Raine) Study were used to identify an early life behavioural endophenotype for atypical hypothalamic-pituitary-adrenocortical function in adolescence, a neurobiological indicator of anxiety and depression. A set of descriptors representing rigid and reactive behaviour at age 1 year discriminated those in the top 20% of the free salivary cortisol exposure at age 17 years. Genetic association analysis revealed a male-sensitive effect to variation in three specific single nucleotide polymorphisms within selected genes underpinning the overall stress response. Furthermore, support for a polygenic effect on stress-related behaviour in childhood is presented.

dc.publisherTaylor & Francis Ltd.
dc.relation.urihttp://onlinelibrary.wiley.com/doi/10.1111/j.1742-9536.2011.00002.x/abstract
dc.subjectunderpinning
dc.subjectpolymorphisms
dc.subjectnucleotide
dc.subjectwithin selected genes
dc.subjectthe overall stress response
dc.titleIdentification and genetic determination of an early life risk disposition for depressive disorder: Atypical stress-related behaviour in early childhood
dc.typeJournal Article
dcterms.source.volume63
dcterms.source.number1
dcterms.source.startPage6
dcterms.source.endPage17
dcterms.source.issn00049530
dcterms.source.titleAustralian Journal of Psychology
curtin.departmentCentre for Developmental Health (Curtin Research Centre)
curtin.accessStatusFulltext not available


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record