Lycopene and prostate cancer: emerging evidence
MetadataShow full item record
Prostate cancer has the third highest incidence of all cancers in men worldwide and is the most common neoplasm diagnosed among men beyond middle age in many developed countries. Mounting evidence surrounding the consumption of tomato products has shown promise for the prevention of prostate cancer. This protective effect has more recently been linked to lycopene, the most abundant carotenoid in tomatoes. Lycopene is a natural pigment that gives the red color to many foods. In Western countries, 85% of dietary lycopene can be attributed to the consumption of tomato-based products. This article reviews emerging evidence from epidemiologic studies for the role of lycopene in prostate cancer prevention. The majority of evidence currently comes from observational studies, but recent human clinical trials and animal studies have provided additional support. Growing evidence on the biologic mechanisms of lycopene in prostate cancer prevention also confirm the epidemiologic findings.
This article is currently embargoed.
Showing items related by title, author, creator and subject.
Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate modelShanmugam, M.; Manu, K.; Ong, T.; Ramachandran, L.; Surana, R.; Bist, P.; Lim, L.; Kumar, Alan Prem; Hui, K.; Sethi, G. (2011)Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel ...
The metabolic syndrome and cancer: Is the metabolic syndrome useful for predicting cancer risk above and beyond its individual components?Harding, J.; Sooriyakumaran, M.; Anstey, K.; Adams, R.; Balkau, B.; Briffa, T.; Davis, T.; Davis, W.; Dobson, A.; Giles, G.; Grant, J.; Knuiman, M.; Luszcz, M.; Mitchell, P.; Pasco, J.; Reid, Christopher; Simmons, D.; Simons, L.; Tonkin, A.; Woodward, M.; Shaw, J.; Magliano, D. (2015)© 2015 Elsevier Masson SAS. Aims: The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than the sum of its individual components, which components ...
Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study Global Burden of Disease Cancer CollaborationFitzmaurice, C.; Allen, C.; Barber, R.; Barregard, L.; Bhutta, Z.; Brenner, H.; Dicker, D.; Chimed-Orchir, O.; Dandona, R.; Dandona, L.; Fleming, T.; Forouzanfar, M.; Hancock, J.; Hay, R.; Hunter-Merrill, R.; Huynh, C.; Hosgood, H.; Johnson, C.; Jonas, J.; Khubchandani, J.; Kumar, G.; Kutz, M.; Lan, Q.; Larson, H.; Liang, X.; Lim, S.; Lopez, A.; MacIntyre, M.; Marczak, L.; Marquez, N.; Mokdad, A.; Pinho, C.; Pourmalek, F.; Salomon, J.; Sanabria, J.; Sandar, L.; Sartorius, B.; Schwartz, S.; Shackelford, K.; Shibuya, K.; Stanaway, J.; Steiner, C.; Sun, J.; Takahashi, K.; Vollset, S.; Vos, T.; Wagner, J.; Wang, H.; Westerman, R.; Zeeb, H.; Zoeckler, L.; Abd-Allah, F.; Ahmed, M.; Alabed, S.; Alam, N.; Aldhahri, S.; Alem, G.; Alemayohu, M.; Ali, R.; Al-Raddadi, R.; Amare, A.; Amoako, Y.; Artaman, A.; Asayesh, H.; Atnafu, N.; Awasthi, A.; Saleem, H.; Barac, A.; Bedi, N.; Bensenor, I.; Berhane, A.; Bernabé, E.; Betsu, B.; Binagwaho, A.; Boneya, D.; Campos-Nonato, I.; Castañeda-Orjuela, C.; Catalá-López, F.; Chiang, P.; Chibueze, C.; Chitheer, A.; Choi, J.; Cowie, B.; Damtew, S.; Das Neves, J.; Dey, S.; Dharmaratne, S.; Dhillon, P.; Ding, E.; Driscoll, T.; Ekwueme, D.; Endries, A.; Farvid, M.; Farzadfar, F.; Fernandes, J.; Miller, Ted (2017)Importance: Cancer is the second leading cause of death worldwide. Current estimates on the burden of cancer are needed for cancer control planning. Objective: To estimate mortality, incidence, years lived with disability ...