Do dietary lycopene and other carotenoids protect against prostate cancer?
MetadataShow full item record
To determine whether dietary intake of lycopene and other carotenoids has an etiological association with prostate cancer, a case-control study was conducted in Hangzhou, southeast China during 2001-2002. The cases were 130 incident patients with histologically confirmed adenocarcinoma of the prostate. The controls were 274 hospital inpatients without prostate cancer or any other malignant diseases. Information on usual food consumption, including vegetables and fruits, was collected by face-to-face interviews using a structured food frequency questionnaire. The risks of prostate cancer for the intake of carotenoids and selected vegetables and fruits rich in carotenoids were assessed using multivariate logistic regression, adjusting for age, locality, education, income, body mass index, marital status, number of children, family history of prostate cancer, tea drinking, total fat and caloric intake. The prostate cancer risk declined with increasing consumption of lycopene, -carotene, -carotene, -cryptoxanthin, lutein and zeaxanthin. Intake of tomatoes, pumpkin, spinach, watermelon and citrus fruits were also inversely associated with the prostate cancer risk. The adjusted odds ratios for the highest versus the lowest quartiles of intake were 0.18 (95% CI: 0.08-0.41) for lycopene, 0.43 (95% CI: 0.21-0.85) for -carotene, 0.34 (95% CI: 0.17-0.69) for -carotene, 0.15 (95% CI: 0.06-0.34) for -cryptoxanthin and 0.02 (95% CI: 0.01-0.10) for lutein and zeaxanthin. The corresponding dose-response relationships were also significant, suggesting that vegetables and fruits rich in lycopene and other carotenoids may be protective against prostate cancer.
Copyright 2005 John Wiley & Sons, Ltd.
Please refer to the publisher for the definitive published version.
Showing items related by title, author, creator and subject.
Jian, Le; Lee, Andy; Binns, Colin (2007)Prostate cancer is the most common male cancer in developed countries and is increasing in the developing world. Its long latency and geographical variation suggest the possibility of prevention or postponement of onset ...
Zhao, J.; Stockwell, T.; Roemer, A.; Chikritzhs, Tanya (2016)Background: Research on a possible causal association between alcohol consumption and risk of prostate cancer is inconclusive. Recent studies on associations between alcohol consumption and other health outcomes suggest ...
Pollard, Christina Mary (2008)Regular consumption of adequate amounts of fruits and vegetables may be protective against chronic disease such as cardiovascular diseases, stroke, and some cancers. Inadequate consumption of fruit and vegetables is a ...