Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life
dc.contributor.author | Braig, S. | |
dc.contributor.author | Brandt, S. | |
dc.contributor.author | Wabitsch, M. | |
dc.contributor.author | Florath, Ines | |
dc.contributor.author | Brenner, H. | |
dc.contributor.author | Rothenbacher, D. | |
dc.contributor.author | Genuneit, J. | |
dc.date.accessioned | 2017-01-30T13:19:47Z | |
dc.date.available | 2017-01-30T13:19:47Z | |
dc.date.created | 2016-02-01T00:47:13Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Braig, S. and Brandt, S. and Wabitsch, M. and Florath, I. and Brenner, H. and Rothenbacher, D. and Genuneit, J. 2014. Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life. Pediatric Allergy and Immunology. 25 (8): pp. 781-787. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/30452 | |
dc.identifier.doi | 10.1111/pai.12280 | |
dc.description.abstract |
© 2014 John Wiley & Sons A/S. Introduction: Asthma is associated with diminished health-related quality of life (HRQoL). Particularly in adolescence, asthma may be under-diagnosed and undertreated or poorly managed. Therefore, we aimed to determine the association between childhood wheezing phenotypes rather than asthma and adolescent HRQoL in children aged 10-17 yr. Methods: We analyzed the data from two prospective population-based cohort studies (n = 604 and n = 1804) conducted in southern Germany with baseline assessments in 2000 and 2006 and follow-ups at frequent intervals. Parent-reported wheeze was categorized into never, early transient, persistent, and late-onset wheeze. We assessed child-reported HRQoL in seven scales using the validated KINDL-R. Multivariate linear regression models were computed. Results: Participants with late-onset wheeze had significantly lower values in all HRQoL scales, but physical well-being compared to never wheezers. Early transient wheeze was negatively associated with three HRQoL scales only (family, school, and total). These effects were confined to the oldest age group (=13.5 yr) in one study. Persistent wheeze was not associated with HRQoL. Conclusions: In teenagers, late-onset wheezers seem to be particularly vulnerable for impairments in psychosocial aspects of health-related quality of life. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.title | Age-specific influence of wheezing phenotypes on pre-adolescent and adolescent health-related quality of life | |
dc.type | Journal Article | |
dcterms.source.volume | 25 | |
dcterms.source.number | 8 | |
dcterms.source.startPage | 781 | |
dcterms.source.endPage | 787 | |
dcterms.source.issn | 0905-6157 | |
dcterms.source.title | Pediatric Allergy and Immunology | |
curtin.department | Epidemiology and Biostatistics | |
curtin.accessStatus | Fulltext not available |
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