Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction

    Access Status
    Open access via publisher
    Authors
    O'Sullivan, J.
    Leblond, A.
    Kelly, G.
    Kumar, A.
    Metharom, Pat
    Büneker, C.
    Alizadeh-Vikali, N.
    Hristova, I.
    Hynes, B.
    O'Connor, R.
    Caplice, N.
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    O'Sullivan, J. and Leblond, A. and Kelly, G. and Kumar, A. and Metharom, P. and Büneker, C. and Alizadeh-Vikali, N. et al. 2011. Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction. Circulation: Cardiovascular Interventions. 4 (4): pp. 327-335.
    Source Title
    Circulation: Cardiovascular Interventions
    DOI
    10.1161/CIRCINTERVENTIONS.110.960765
    ISSN
    1941-7640
    Faculty
    Faculty of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/30558
    Collection
    • Curtin Research Publications
    Abstract

    Background-Insulin-like growth factor-1 (IGF-1) is recognized as an important regulator of cardiac structure and cardiomyocyte homeostasis. The prosurvival and antiapoptotic effects of IGF-1 have been investigated in vitro and in rodent models of myocardial infarction (MI). However, the clinical application of IGF-1 has been hampered by dose-dependent side effects both acutely and during chronic administration. We hypothesized that single, low-dose IGF-1 (LD-IGF-1) administered locally and early in the reperfusion phase after acute MI in a large animal model would avoid significant side effects but would have prosurvival effects that would manifest in long-term structural and functional improvement after MI treatment. Methods and Results-Forty-four female Landrace pigs underwent intracoronary administration of LD-IGF-1 or saline 2 hours into the reperfusion phase of acute left anterior descending artery occlusion MI. In the area of infarction, IGF-1 receptor and signaling responses were activated at 30 minutes and cardiomyocyte cell death attenuated at 24 hours after LD-IGF-1 but not saline treatment. Hemodynamic and structural studies using pressure-volume loop, CT, and triphenyltetrazolium chloride analysis 2 months post-MI confirmed a marked reduction in infarct size, attenuation of wall thinning, and augmentation of wall motion in the LD-IGF-1-treated but not in the saline-treated animals. These regional structural benefits were associated with global reductions in left ventricular volumes and significant improvement in left ventricular systolic and diastolic function. Conclusions-One-time LD-IGF-1 effects potent acute myocardial salvage in a preclinical model of left anterior descending artery occlusive MI, extending to long-term benefits in MI size, wall structure, and function and underscoring its potential as an adjunctive therapeutic agent. © 2011 American Heart Association, Inc.

    Related items

    Showing items related by title, author, creator and subject.

    • A randomized controlled trial of oxygen therapy in acute myocardial infarction Air Verses Oxygen in myocarDial infarction study (AVOID Study)
      Stub, D.; Smith, K.; Bernard, S.; Bray, Janet; Stephenson, M.; Cameron, P.; Meredith, I.; Kaye, D. (2012)
      Background: The role of routine supplemental oxygen for patients with uncomplicated acute myocardial infarction (AMI) has recently been questioned. There is conflicting data on the possible effects of hyperoxia on ischemic ...
    • Effect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention : Insights From a Multi-Centre Australian PCI Registry
      Papapostolou, S.; Dinh, D.T.; Noaman, S.; Biswas, S.; Duffy, S.J.; Stub, D.; Shaw, J.A.; Walton, A.; Sharma, A.; Brennan, A.; Clark, D.; Freeman, M.; Yip, T.; Ajani, A.; Reid, Christopher ; Oqueli, E.; Chan, W. (2021)
      Objectives: To evaluate the effect of age in an all-comers population undergoing percutaneous coronary intervention (PCI). Background: Age is an important consideration in determining appropriateness for invasive cardiac ...
    • Haemodynamic evaluation of coronary artery plaques : prediction of coronary atherosclerosis and disease progression
      Chaichana, Thanapong (2012)
      Coronary artery disease is the leading cause of death in advanced countries. Coronary artery disease tends to develop at locations where disturbed flow patterns occur, such as the left coronary artery. Haemodynamic change ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.