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    A randomized controlled trial of oxygen therapy in acute myocardial infarction Air Verses Oxygen in myocarDial infarction study (AVOID Study)

    Access Status
    Fulltext not available
    Authors
    Stub, D.
    Smith, K.
    Bernard, S.
    Bray, Janet
    Stephenson, M.
    Cameron, P.
    Meredith, I.
    Kaye, D.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Stub, D. and Smith, K. and Bernard, S. and Bray, J. and Stephenson, M. and Cameron, P. and Meredith, I. et al. 2012. A randomized controlled trial of oxygen therapy in acute myocardial infarction Air Verses Oxygen in myocarDial infarction study (AVOID Study). American Heart Journal. 163 (3): pp. 339-345.e1.
    Source Title
    American Heart Journal
    DOI
    10.1016/j.ahj.2011.11.011
    ISSN
    0002-8703
    School
    School of Nursing and Midwifery
    URI
    http://hdl.handle.net/20.500.11937/7655
    Collection
    • Curtin Research Publications
    Abstract

    Background: The role of routine supplemental oxygen for patients with uncomplicated acute myocardial infarction (AMI) has recently been questioned. There is conflicting data on the possible effects of hyperoxia on ischemic myocardium. The few clinical trials examining the role of oxygen in AMI were performed prior to the modern approach of emergent reperfusion and advanced medical management. Methods: Air Verses Oxygen In myocarDial infarction study (AVOID Study) is a prospective, multi-centre, randomized, controlled trial conducted by Ambulance Victoria and participating metropolitan Melbourne hospitals with primary percutaneous coronary intervention capabilities. The purpose of the study is to determine whether withholding routine supplemental oxygen therapy in patients with acute ST-elevation myocardial infarction but without hypoxia prior to reperfusion decreases myocardial infarct size. AVOID will enroll 490 patients, >18 years of age with acute ST-elevation myocardial infarction of less than 12 hours duration. Conclusions: There is an urgent need for clinical trials examining the role of oxygen in AMI. AVOID will seek to clarify this important issue. Results from this study may have widespread implications on the treatment of AMI and the use of oxygen in both the pre-hospital and hospital settings.

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