Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Distribution of the single nucleotide polymorphism C3435T of MDR1 gene among people in Western Australia, Australia

    194102_99464_Omar_IJPPS_2013.pdf (781.0Kb)
    Access Status
    Open access
    Authors
    Omar, Marhanis
    Crowe, Andrew
    Hughes, Jeffrey
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Omar, Marhanis S. and Crowe, Andrew and Hughes, Jeffrey. 2013. Distribution of the single nucleotide polymorphism C3435T of MDR1 gene among people in Western Australia, Australia. International Journal of Pharmacy and Pharmaceutical Sciences. 5 (Suppl 4): pp. 470-473.
    Source Title
    International Journal of Pharmacy and Pharmaceutical Sciences
    Additional URLs
    http://ijppsjournal.com
    ISSN
    0975-1491
    Remarks

    This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

    URI
    http://hdl.handle.net/20.500.11937/30718
    Collection
    • Curtin Research Publications
    Abstract

    What is known: Ethnic variation as well as the population frequency of the MDR1 C3435T transition has been observed in the few other populations but not in Australians. Objective: This study aimed to investigate the distribution of the single nucleotide polymorphism C3435T in exon 26 of the MDR1 gene among people in Western Australia, Australia. Methods: Blood samples were collected from participants from a tertiary hospital in Western Australia from October 2010 to July 2011. The MDR1 C3435T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: It was found that the frequency of the homozygous 3435TT allele among the subjects was 30.77% compared to the 21.98% that carries the homozygous 3435CC allele while almost half of our study subjects are carrying the heterozygous 3435CT allele. Our study shows similarity with C3435T genotype distribution among New Zealander and Asians population which could be attributed to the close geography between Australia and New Zealand with other part of Asia and possibly due to high migration between these countries. What is New: This study included Australian patients. Conclusion: This is the first study to illustrate the distribution of MDR1 C3435T genotypes for Australians that could be useful in predicting risk for certain disease and beneficial in tailoring a patient`s drug regimen.

    Related items

    Showing items related by title, author, creator and subject.

    • P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism
      Omar, Marhanis; Crowe, Andrew; Parsons, Richard; Ee, H.; Tay, C.; Hughes, Jeffery (2012)
      OBJECTIVE: The aim of this study was to determine whether the presence of Helicobacter pylori (H. pylori) infection and multidrug resistance protein 1 (MDR1) C3435T polymorphism had an influence on P-glycoprotein (P-gp) ...
    • Magnitude and contributory factors of postnatal depression: A community-based cohort study from a rural sub-district of Bangladesh
      Gausia, K.; Fisher, C.; Ali, Mohammed; Oosthuizen, J. (2009)
      Background: Recent evidence suggests that the prevalence of postnatal depression (PND) is highest in low-income developing countries. This study aimed to estimate the prevalence of PND and its associated risk factors among ...
    • Characterization of Leaf Transcriptome in Banksia hookeriana
      Lim, S.; D'Agui, H.; Enright, N.; He, Tianhua (2017)
      Banksia is a significant element in vegetation of southwestern Australia, a biodiversity hotspot with global significance. In particular, Banksia hookeriana represents a species with significant economic and ecological ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.