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    P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism

    Access Status
    Fulltext not available
    Authors
    Omar, Marhanis
    Crowe, Andrew
    Parsons, Richard
    Ee, H.
    Tay, C.
    Hughes, Jeffery
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Omar, Marhanis and Crowe, Andrew and Parsons, Richard and EE, Hooi and Tay, Chin and Hughes, Jeffery. 2012. P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism. Journal of Digestive Diseases. 13 (8): pp. 414-420.
    Source Title
    Journal of Digestive Diseases
    DOI
    10.1111/j.1751-2980.2012.00606.x
    ISSN
    1751-2972
    URI
    http://hdl.handle.net/20.500.11937/11169
    Collection
    • Curtin Research Publications
    Abstract

    OBJECTIVE: The aim of this study was to determine whether the presence of Helicobacter pylori (H. pylori) infection and multidrug resistance protein 1 (MDR1) C3435T polymorphism had an influence on P-glycoprotein (P-gp) expression in the upper gastrointestinal tract. METHODS: A total of 76 patients who underwent upper gastroendoscopy at Sir Charles Gairdner Hospital in Western Australia from October 2010 to July 2011 were enrolled in the study. Antral and duodenal biopsies were collected for P-gp examination. Blood samples were taken and analyzed for MDR1 C3435T polymorphism. H. pylori infection status was confirmed by culture and polymerase chain reaction. RESULTS: A significant difference was found in P-gp expression between H. pylori-positive and H. pylori-negative patients (P = 0.028). For the MDR1 C3435T polymorphism, the TT genotype had a significantly lower P-gp expression compared with the CC genotype in antral specimens (P = 0.041). The homozygous TT genotype with H. pylori infection was also significantly different in P-gp expression compared with H. pylori-negative patients (P = 0.029). CONCLUSIONS: P-gp expression in the upper gastrointestinal tract is associated with H. pylori infection, and the TT genotype appeared to be associated with lower P-gp expression than the CC genotype in the stomach.

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      What is known: Ethnic variation as well as the population frequency of the MDR1 C3435T transition has been observed in the few other populations but not in Australians. Objective: This study aimed to investigate the ...
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      The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic ...
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