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Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening

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Authors
Gunosewoyo, Hendra
Coster, M.
Bennett, M.
Kassiou, M.
Date
2009
Type
Journal Article

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Gunosewoyo, Hendra and Coster, Mark J. and Bennett, Maxwell R. and Kassiou, Michael. 2009. Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening. Bioorganic & Medicinal Chemistry. 17 (14): pp. 4861-4865.
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Bioorganic & Medicinal Chemistry
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Abstract

The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.