Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening
| dc.contributor.author | Gunosewoyo, Hendra | |
| dc.contributor.author | Coster, M. | |
| dc.contributor.author | Bennett, M. | |
| dc.contributor.author | Kassiou, M. | |
| dc.date.accessioned | 2017-01-30T13:22:22Z | |
| dc.date.available | 2017-01-30T13:22:22Z | |
| dc.date.created | 2014-02-18T20:00:21Z | |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Gunosewoyo, Hendra and Coster, Mark J. and Bennett, Maxwell R. and Kassiou, Michael. 2009. Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening. Bioorganic & Medicinal Chemistry. 17 (14): pp. 4861-4865. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/30938 | |
| dc.identifier.doi | 10.1016/j.bmc.2009.05.083 | |
| dc.description.abstract |
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry. | |
| dc.publisher | Pergamon | |
| dc.subject | P2X7 antagonists | |
| dc.subject | LL-37 | |
| dc.subject | Rational drug design | |
| dc.subject | Cytokine release | |
| dc.title | Purinergic P2X7 Receptor Antagonists: Chemistry and Fundamentals of Biological Screening | |
| dc.type | Journal Article | |
| dcterms.source.volume | 17 | |
| dcterms.source.number | 14 | |
| dcterms.source.startPage | 4861 | |
| dcterms.source.endPage | 4865 | |
| dcterms.source.issn | 0968-0896 | |
| dcterms.source.title | Bioorganic & Medicinal Chemistry | |
| curtin.department | ||
| curtin.accessStatus | Fulltext not available |