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    Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status

    Access Status
    Fulltext not available
    Authors
    Foster, J.
    Albrecht, Matthew
    Szoeke, C.
    Maruff, P.
    Savage, G.
    Lautenschlager, N.
    Ellis, K.
    Taddei, K.
    Martins, R.
    Masters, C.
    Ames, D.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Foster, J. and Albrecht, M. and Szoeke, C. and Maruff, P. and Savage, G. and Lautenschlager, N. and Ellis, K. et al. 2014. Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status. Alzheimer's and Dementia. 10 (4) Suppl.: pp. P220-P221.
    Source Title
    Alzheimer's and Dementia
    DOI
    10.1016/j.jalz.2014.04.303
    ISSN
    1552-5260
    School
    School of Psychology
    URI
    http://hdl.handle.net/20.500.11937/3155
    Collection
    • Curtin Research Publications
    Abstract

    The ε4 polymorphism of the APOE gene confers a substantially increased risk of developing Alzheimer's disease (AD). However, the influence of the ε4 allele on cognitive functioning in ageing individuals is more contentious. Previously, we demonstrated relatively little evidence for a role of the ε4 allele on baseline cognitive performance in older adults in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing (Foster et al [2013], BRAIN, 136, 2201-16). We here investigated whether the APOE ε4 allele influenced cognitive status over time when the AIBL cohort was followed longitudinally over a 3-year period.

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