Longitudinal cognitive decline in the AIBL cohort: the role of APOE ε4 status
MetadataShow full item record
The ε4 polymorphism of the APOE gene confers a substantially increased risk of developing Alzheimer's disease (AD). However, the influence of the ε4 allele on cognitive functioning in ageing individuals is more contentious. Previously, we demonstrated relatively little evidence for a role of the ε4 allele on baseline cognitive performance in older adults in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing (Foster et al , BRAIN, 136, 2201-16). We here investigated whether the APOE ε4 allele influenced cognitive status over time when the AIBL cohort was followed longitudinally over a 3-year period.
Showing items related by title, author, creator and subject.
Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled TrialLawrence, B.; Gasson, Natalie; Johnson, A.; Booth, L.; Loftus, A. (2018)Â© 2018 Blake J. Lawrence et al. This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive ...
Cognitive Training and Noninvasive Brain Stimulation for Cognition in Parkinson's Disease: A Meta-analysis.Lawrence, B.; Gasson, Natalie; Bucks, R.; Troeung, L.; Loftus, A. (2017)BACKGROUND: Many people with Parkinson's disease (PD) experience cognitive decline. It is not known whether cognitive training or noninvasive brain stimulation are effective at alleviating cognitive deficits in PD. ...
Utility of an Alzheimer's Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer's Disease: A Prospective Longitudinal Study.Porter, T.; Burnham, S.; Milicic, L.; Savage, G.; Maruff, P.; Lim, Y.; Li, Q.; Ames, D.; Masters, C.; Rainey-Smith, S.; Rowe, C.; Salvado, O.; Groth, D.; Verdile, Giuseppe; Villemagne, V.; Laws, S.; AIBL Research Group (2018)BACKGROUND: With the exception of APOE, genetic variants associated with increased Alzheimer's disease (AD) risk are characterized by small effect sizes. Polygenic risk scores (PRS) have shown utility in predicting AD ...