Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Human pancreatic islet transplantation: an update and description of the establishment of a pancreatic islet isolation laboratory

    239156_239156.pdf (234.5Kb)
    Access Status
    Open access
    Authors
    Rheinheimer, J.
    Bauer, A.
    Silveiro, S.
    Estivalet, A.
    Bouças, A.
    Rosa, A.
    de Souza, B.
    de Oliveira, F.
    Cruz, L.
    Brondani, L.
    Azevedo, M.
    Lemos, N.
    Carlessi, Rodrigo
    Assmann, T.
    Gross, J.
    Leitão, C.
    Crispim, D.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Rheinheimer, J. and Bauer, A. and Silveiro, S. and Estivalet, A. and Bouças, A. and Rosa, A. and de Souza, B. et al. 2015. Human pancreatic islet transplantation: an update and description of the establishment of a pancreatic islet isolation laboratory. Archives of Endocrinology and Metabolism. 59 (2): pp. 161-170.
    Source Title
    Arch Endocrinol Metab
    DOI
    10.1590/2359-3997000000030
    School
    School of Biomedical Sciences
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc/3.0/deed.en

    URI
    http://hdl.handle.net/20.500.11937/31915
    Collection
    • Curtin Research Publications
    Abstract

    Type 1 diabetes mellitus (T1DM) is associated with chronic complications that lead to high morbidity and mortality rates in young adults of productive age. Intensive insulin therapy has been able to reduce the likelihood of the development of chronic diabetes complications. However, this treatment is still associated with an increased incidence of hypoglycemia. In patients with "brittle T1DM", who have severe hypoglycemia without adrenergic symptoms (hypoglycemia unawareness), islet transplantation may be a therapeutic option to restore both insulin secretion and hypoglycemic perception. The Edmonton group demonstrated that most patients who received islet infusions from more than one donor and were treated with steroid-free immunosuppressive drugs displayed a considerable decline in the initial insulin independence rates at eight years following the transplantation, but showed permanent C-peptide secretion, which facilitated glycemic control and protected patients against hypoglycemic episodes. Recently, data published by the Collaborative Islet Transplant Registry (CITR) has revealed that approximately 50% of the patients who undergo islet transplantation are insulin independent after a 3-year follow-up. Therefore, islet transplantation is able to successfully decrease plasma glucose and HbA1c levels, the occurrence of severe hypoglycemia, and improve patient quality of life. The goal of this paper was to review the human islet isolation and transplantation processes, and to describe the establishment of a human islet isolation laboratory at the Endocrine Division of the Hospital de Clínicas de Porto Alegre - Rio Grande do Sul, Brazil.

    Related items

    Showing items related by title, author, creator and subject.

    • Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation
      Cohrs, C.; Chen, C.; Jahn, S.; Stertmann, J.; Chmelova, H.; Weitz, J.; Bähr, A.; Klymiuk, N.; Steffen, A.; Ludwig, B.; Kamvissi, V.; Wolf, E.; Bornstein, S.; Solimena, Michele; Speier, S. (2017)
      Copyright © 2017 Endocrine Society. Islet-cell hormone release is modulated by signals from endothelial and endocrine cells within the islet. However, models of intraislet vascularization and paracrine cell signaling are ...
    • Mesenchymal stem cells protect islets from hypoxia/reoxygenation-induced injury
      Lu, Y.; Jin, X.; Chen, Younan; Li, S.; Yuan, Y.; Mai, G.; Tian, B.; Long, D.; Zhang, J.; Zeng, L.; Li, Y.; Cheng, J. (2010)
      Hypoxia/reoxygenation (H/R)-induced injury is the key factor associated with islet graft dysfunction. This study aims to examine the effect of mesenchymal stem cells (MSCs) on islet survival and insulin secretion under ...
    • Hypoglycemia in Insulin-Treated Adults on Established Nasogastric Feeding in the General Ward
      Vindedzis, S.; Sherriff, Jill; Stanton, K. (2014)
      Purpose: This study aimed to address 2 questions: First, what are the existing summary statistics of frequency of hypoglycemia in insulin-treated adults on established nasogastric feeding in the general ward? Second, to ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.