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    Characterisation of the Melanocortin 1 Receptor gene in Alpaca and identification of possible markers associated with phenotypic variations

    131355_131355-%20Feeley%20%20Munyard%20Alpaca%20MC1R.pdf (104.5Kb)
    Access Status
    Open access
    Authors
    Feeley, Natasha
    Munyard, Kylie
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Feeley, Natasha and Munyard, Kylie. 2009. Characterisation of the Melanocortin 1 Receptor gene in Alpaca and identification of possible markers associated with phenotypic variations. Animal Production Science 49 (8): pp. 675-681.
    Source Title
    Animal Production Science
    DOI
    10.1071/AN09005
    ISSN
    18360939
    Faculty
    Faculty of Health Sciences
    School of Biomedical Sciences
    Remarks

    © 2008 CSIRO Publishing

    URI
    http://hdl.handle.net/20.500.11937/32070
    Collection
    • Curtin Research Publications
    Abstract

    The aim of this study was to determine if any correlation exists between MC1R polymorphisms, and skin and fibre colour in alpacas. Primers capable of amplifying the entire alpaca MC1R were designed from a comparative alignment of Bos taurus and Mus musculus MC1R gene sequences. The complete MC1R of 36 alpacas exhibiting a range of fibre colours, and which were sourced from farms across Australia, was sequenced from PCR products. Twenty one single nucleotide polymorphisms were identified within MC1R. Two of these polymorphisms (A82G and C901T) have the potential to reduce eumelanin production by disrupting the activity of MC1R. No agreement was observed between fibre colour alone, and MC1R genotype in the 36 animals in this study. However, when the animals were assigned to groups based on the presence or absence of eumelanin in their fibre and skin; only animals that had at least one allele with the A82/ C901 combination expressed eumelanin. We propose that A82/ C901 is the wildtype dominant 'E' MC1R allele, while alpacas with either G82/ T901 or G82/ Y901 are homozygous for the recessive 'e' MC1R allele and are therefore unable to produce eumelanin.

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