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    Effects of Migrating Cell-Induced Matrix Reorganization on 3D Cancer Cell Migration

    Access Status
    Fulltext not available
    Authors
    Sun, W.
    Kurniawan, N.
    Kumar, Alan Prem
    Rajagopalan, R.
    Lim, C.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Sun, W. and Kurniawan, N. and Kumar, A.P. and Rajagopalan, R. and Lim, C. 2014. Effects of Migrating Cell-Induced Matrix Reorganization on 3D Cancer Cell Migration. Cellular and Molecular Bioengineering. 7 (2): pp. 205-217.
    Source Title
    Cellular and Molecular Bioengineering
    DOI
    10.1007/s12195-014-0324-0
    ISSN
    1865-5025
    URI
    http://hdl.handle.net/20.500.11937/32537
    Collection
    • Curtin Research Publications
    Abstract

    The migration of cells is fundamental to a number of physiological/pathological processes, ranging from embryonic development, tissue regeneration to cancer metastasis. Current research on cell migration is largely based on simplified in vitro models that assume a homogeneous microenvironment and overlook the modification of extracellular matrix (ECM) by the cells. To address this shortcoming, we developed a nested three-dimensional (3D) collagen hydrogel model mimicking the connective tissue confronted by highly malignant breast cancer cells, MDA-MB-231. Strikingly, our findings revealed two distinct cell migration patterns: a rapid and directionally persistent collective migration of the leader cells and a more randomized migration in the regions that have previously been significantly modified by cells. The cell-induced modifications, which typically include clustering and alignment of fibers, effectively segmented the matrix into smaller sub-regions. Our results suggest that in an elastic 3D matrix, the presence of adjacent cells that have modified the matrix may in fact become physical hurdle to a migrating cell. Furthermore, our study emphasizes the need for a micromechanical understanding in the context of cancer invasion that allows for cell-induced modification of ECM and a heterogeneous cell migration.

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