Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Rhenium tetrazolato complexes coordinated to thioalkyl-functionalised phenanthroline ligands: Synthesis, photophysical characterisation, and incubation in live HeLa cells

    235328_235328.pdf (1.272Mb)
    Access Status
    Open access
    Authors
    Werrett, Melissa
    Wright, Phillip
    Simpson, Peter
    Raiteri, Paolo
    Skelton, B.
    Stagni, S.
    Buckley, A.
    Rigby, P.
    Massi, Massimiliano
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Werrett, M. and Wright, P. and Simpson, P. and Raiteri, P. and Skelton, B. and Stagni, S. and Buckley, A. et al. 2015. Rhenium tetrazolato complexes coordinated to thioalkyl-functionalised phenanthroline ligands: Synthesis, photophysical characterisation, and incubation in live HeLa cells. Dalton Transactions. 44 (47): pp. 20636-20647.
    Source Title
    Dalton Transactions
    DOI
    10.1039/c5dt03470a
    ISSN
    1477-9226
    School
    Department of Chemistry
    URI
    http://hdl.handle.net/20.500.11937/33212
    Collection
    • Curtin Research Publications
    Abstract

    © The Royal Society of Chemistry 2015. Three new complexes of formulation fac-[Re(CO)3(diim)L], where diim is either 1,10-phenanthroline or 1,10-phenanthroline functionalised at position 5 by a thioalkyl chain, and L is either a chloro or aryltetrazolato ancillary ligand, were synthesised and photophysically characterised. The complexes exhibit phosphorescent emission with maxima around 600 nm, originating from triplet metal-to-ligand charge transfer states with partially mixed ligand-to-ligand charge transfer character. The emission is relatively long-lived, within the 200-400 ns range, and with quantum yields of 2-4%. The complexes were trialed as cellular markers in live HeLa cells, along with two previously reported rhenium tetrazolato complexes bound to unsubstituted 1,10-phenanthroline. All five complexes exhibit good cellular uptake and non-specific perinuclear localisation. Upon excitation at 405 nm, the emission from the rhenium complexes could be clearly distinguished from autofluorescence, as demonstrated by spectral detection within the live cells. Four of the complexes did not appear to be toxic, however prolonged excitation could result in membrane blebbing. No major sign of photobleaching was detected upon multiple imaging on the same cell sample.

    Related items

    Showing items related by title, author, creator and subject.

    • Methylated Re(i) tetrazolato complexes: Photophysical properties and Light Emitting Devices
      Werrett, M.; Huff, G.; Muzzioli, S.; Fiorini, V.; Zacchini, S.; Skelton, B.; Maggiore, A.; Malicka, J.; Cocchi, M.; Gordon, K.; Stagni, S.; Massi, Massimiliano (2015)
      The irreversible reaction of methyl triflate with neutral Re(I) tetrazolato complexes of the type fac-[Re(diim)(CO)3(L)], where diim is either 1,10-phenanthroline or 2,2′-bipyridine and L is a para substituted 5-aryltetrazolate, ...
    • Photophysical and biological investigation of phenol substituted rhenium tetrazolato complexes
      Akabar, N.; Chaturvedi, V.; Shillito, G.E.; Schwehr, Brad ; Gordon, K.C.; Huff, G.S.; Sutton, J.J.; Skelton, B.W.; Sobolev, A.N.; Stagni, S.; Nelson, Delia ; Massi, Max (2019)
      The synthesis, structural and photophysical characterisation of four tricarbonyl rhenium(i) complexes bound to 1,10-phenanthroline and a tetrazolato ancillary ligand are reported. The complexes are differentiated by the ...
    • Imaging nuclear, endoplasmic reticulum, and plasma membrane events in real time
      Bader, C.; Sorvina, A.; Simpson, Peter; Wright, P.; Stagni, S.; Plush, S.; Massi, Massimiliano; Brooks, D. (2016)
      Live cell imaging can provide important information on cellular dynamics; however, the full utilisation of this technology has been hampered by the limitations of imaging reagents. Metal-based complexes have the potential ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.