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    Photophysical and biological investigation of phenol substituted rhenium tetrazolato complexes

    91826.pdf (1.446Mb)
    91826_supplementary.pdf (3.006Mb)
    Access Status
    Open access
    Authors
    Akabar, N.
    Chaturvedi, V.
    Shillito, G.E.
    Schwehr, Brad
    Gordon, K.C.
    Huff, G.S.
    Sutton, J.J.
    Skelton, B.W.
    Sobolev, A.N.
    Stagni, S.
    Nelson, Delia
    Massi, Max
    Date
    2019
    Type
    Journal Article
    
    Metadata
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    Citation
    Akabar, N. and Chaturvedi, V. and Shillito, G.E. and Schwehr, B.J. and Gordon, K.C. and Huff, G.S. and Sutton, J.J. et al. 2019. Photophysical and biological investigation of phenol substituted rhenium tetrazolato complexes. Dalton Transactions. 48 (41): pp. 15613-15624.
    Source Title
    Dalton Transactions
    DOI
    10.1039/c9dt02198a
    ISSN
    1477-9226
    Faculty
    Faculty of Science and Engineering
    Faculty of Health Sciences
    School
    School of Molecular and Life Sciences (MLS)
    Curtin Medical School
    Funding and Sponsorship
    http://purl.org/au-research/grants/arc/FT130100033
    http://purl.org/au-research/grants/arc/LE130100052
    URI
    http://hdl.handle.net/20.500.11937/92002
    Collection
    • Curtin Research Publications
    Abstract

    The synthesis, structural and photophysical characterisation of four tricarbonyl rhenium(i) complexes bound to 1,10-phenanthroline and a tetrazolato ancillary ligand are reported. The complexes are differentiated by the nature (hydroxy or methoxy) and position (meta or para) of the substituent attached to the phenyl ring in conjugation to the tetrazole ring. The complexes exhibit phosphorescence emission from triplet charge transfer excited states, with the maxima around 600 nm, excited state lifetime decays in the 200-300 ns range, and quantum yield values of 4-6% in degassed acetonitrile solutions. The nature and position of the substituent does not significantly affect the photophysical properties, which remain unchanged even after deprotonation of the hydroxide group on the phenol ring. The interpretation of the photophysical data was further validated by resonance Raman spectroscopy and time-dependent density functional theory calculations. All the complexes are internalised within cells, albeit to variable degrees. As highlighted by a combination of flow cytometry and confocal microscopy, the species display diffuse cytoplasmic localisation except for the complex with the hydroxy functional group at the para position, which reveals lower accumulation in cells and more pronounced punctate staining. Overall, the complexes displayed low levels of cytotoxicity.

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