The Efficacy of Quercetin in Cardiovascular Health
MetadataShow full item record
Cardiovascular disease is a major cause of death worldwide despite the majority of its risk factors being preventable and treatable. The results of numerous epidemiological studies suggest that a diet rich in fruits and vegetables affords protection against CVD, and this may be attributed, in part, to the flavonoid quercetin. The aims of this review are to summarise the current knowledge on the bioavailability and metabolism of quercetin as well as discuss the current evidence behind the potential mechanisms by which quercetin exerts its cardioprotective effects. This review summarises key human studies administering quercetin that have been published to date. Although interesting results have been seen in animal and cell culture studies, in general, these have not been replicated in human trials. Several studies have, however, shown that quercetin can reduce blood pressure in hypertensive patients. The exact mechanisms are yet to be elucidated. Further studies are required to investigate the use of quercetin as a cardioprotective treatment, in particular long-term and dose–response studies.
Showing items related by title, author, creator and subject.
Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPKShen, Y.; Croft, K.; Hodgson, J.; Kyle, R.; Lee, I.; Wang, Y.; Stocker, R.; Ward, Natalie (2012)Quercetin is a major flavonoid in a wide range of fruits and vegetables. Consumption of quercetin may contribute to a reduction in risk of cardiovascular disease (CVD). Following ingestion, flavonoids are metabolized ...
Acute effects of quercetin-3-O-glucoside on endothelial function and blood pressure: a randomized dose-response studyBondonno, N.; Bondonno, C.; Rich, L.; Mas, E.; Shinde, S.; Ward, Natalie; Hodgson, J.; Croft, K. (2016)Background: Epidemiologic studies have suggested that a flavonoid-rich diet can reduce the risk of developing cardiovascular disease. Certain flavonoids, in particular quercetin, have been shown to ameliorate endothelial ...
Regulation of fruit colour development, quality and storage life of ‘Cripps Pink’ apple with deficit irrigation and plant bioregulatorsWan Sembok, Wan Zaliha Binti (2009)Poor and erratic fruit colour development in ‘Cripps Pink’ apple causes serious economic losses to the growers and/or exporters of Western Australia and other parts of the world. Many internal and external factors such ...