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    Prospective audit of exudative age-related macular degeneration: 12-month outcomes in treatment-naïve eyes

    Access Status
    Open access via publisher
    Authors
    Gillies, M.
    Walton, R.
    Simpson, J.
    Arnold, J.
    Guymer, R.
    McAllister, I.
    Hunyor, A.
    Essex, R.
    Morlet, Nigel
    Barthelmes, D.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Gillies, M. and Walton, R. and Simpson, J. and Arnold, J. and Guymer, R. and McAllister, I. and Hunyor, A. et al. 2013. Prospective audit of exudative age-related macular degeneration: 12-month outcomes in treatment-naïve eyes. Investigative Ophthalmology and Visual Science. 54 (8): pp. 5754-5760.
    Source Title
    Investigative Ophthalmology and Visual Science
    DOI
    10.1167/iovs.13-11993
    ISSN
    0146-0404
    School
    Centre for Population Health Research
    URI
    http://hdl.handle.net/20.500.11937/33849
    Collection
    • Curtin Research Publications
    Abstract

    PURPOSE. We report the 12-month outcomes of 1140 treatment-naïve eyes with exudative agerelated macular degeneration (wet AMD) who were treated for 12 months with intravitreal anti-VEGF drugs in routine clinical practice. METHODS. Index visit characteristics, such as lesion type and size, visual acuity (VA, in Logarithm of the Minimal Angle of Resolution [logMAR] letters), as well as treatments, outcomes (VA, lesion activity status) and ocular adverse events were recorded in a prospectively designed electronic database. Index visit characteristics associated with the 12-month VA outcome were identified using mixed effects linear regression. RESULTS. Mean change in VA in the cohort after 12 months was +4.7 logMAR letters (95% confidence interval [CI], 3.4-6.1) with a mean of 7.0 injections. No significant difference was found in change in VA, or number of injections by type or size of the lesion. Median time to inactivation of lesions was 194 days. VA at the index visit was the strongest predictor for the 12-month outcomes. Infectious endophthalmitis occurred in 2 cases, and retinal detachment occurred in 1 case from a total of 9162 injections. CONCLUSIONS. These findings indicate that VEGF inhibitors can achieve reasonably good outcomes for wet AMD when used in routine clinical practice. © 2013 Association for Research in Vision and Ophthalmology, Inc.

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