Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses
MetadataShow full item record
Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Ra I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p = 0.01, TetTox p = 0.04; IL-4Ra.I50V: DipTox p = 0.04, TetTox p = 0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p = 0.03) and TetTox (p = 0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p = 0.01) and IL-4Ra I50V (p = 0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses. © 2008 Elsevier Ltd. All rights reserved.
Showing items related by title, author, creator and subject.
CD46 measles virus receptor polymorphisms influence receptor protein expression and primary measles vaccine responses in naive australian childrenClifford, H.; Hayden, C.; Khoo, S.; Zhang, Guicheng; Le Souëf, P.; Richmonda, P. (2012)Despite the availability of measles vaccines, infants continue to die from measles. Measles vaccine responses vary between individuals, and poor immunogenicity is likely to preclude protection against measles. CD46 is a ...
TLR3 and RIG-I gene variants: Associations with functional effects on receptor expression and responses to measles virus and vaccine in vaccinated infantsClifford, H.; Yerkovich, S.; Khoo, S.; Zhang, Guicheng; Upham, J.; Le Souëf, P.; Richmond, P.; Hayden, C. (2012)Measles virus causes severe morbidity and mortality, despite the availability of measles vaccines. Successful defence against viral pathogens requires early recognition of virus-specific patterns by innate receptors like ...
Genetic Variants in the IL-4/IL-13 Pathway Influence Measles Vaccine Responses and Vaccine Failure in Children from Mozambique.Clifford, H.; Hayden, C.; Khoo, S.; Naniche, D.; Mandomando, I.; Zhang, Guicheng; Richmond, P.; Le Souëf, P. (2017)Despite effective measles vaccines, measles still causes severe morbidity and mortality worldwide, particularly in developing countries. The Th2 pathway involving interleukin (IL)-4 and IL-13 cytokines, and their receptor ...