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dc.contributor.authorBaynam, G.
dc.contributor.authorZhang, Guicheng
dc.contributor.authorKhoo, S.
dc.contributor.authorSly, P.
dc.contributor.authorHolt, P.
dc.contributor.authorGoldblatt, J.
dc.contributor.authorLe Souëf, P.
dc.date.accessioned2017-01-30T13:41:03Z
dc.date.available2017-01-30T13:41:03Z
dc.date.created2016-09-12T08:36:29Z
dc.date.issued2008
dc.identifier.citationBaynam, G. and Zhang, G. and Khoo, S. and Sly, P. and Holt, P. and Goldblatt, J. and Le Souëf, P. 2008. Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses. Vaccine. 26 (29-30): pp. 3574-3579.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/34065
dc.identifier.doi10.1016/j.vaccine.2008.05.011
dc.description.abstract

Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Ra I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p = 0.01, TetTox p = 0.04; IL-4Ra.I50V: DipTox p = 0.04, TetTox p = 0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p = 0.03) and TetTox (p = 0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p = 0.01) and IL-4Ra I50V (p = 0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses. © 2008 Elsevier Ltd. All rights reserved.

dc.publisherElsevier
dc.titleGender-specific effects of cytokine gene polymorphisms on childhood vaccine responses
dc.typeJournal Article
dcterms.source.volume26
dcterms.source.number29-30
dcterms.source.startPage3574
dcterms.source.endPage3579
dcterms.source.issn0264-410X
dcterms.source.titleVaccine
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available


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