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    Histomorphometric and radiographical changes after lumbar implantation of the PEEK nonfusion interspinous device in the BB.4S rat model

    Access Status
    Fulltext not available
    Authors
    Barz, T.
    Lange, J.
    Melloh, Markus
    Staub, L.
    Merk, H.
    Klöting, I.
    Follak, N.
    Date
    2013
    Type
    Journal Article
    
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    Citation
    Barz, T. and Lange, J. and Melloh, M. and Staub, L. and Merk, H. and Klöting, I. and Follak, N. 2013. Histomorphometric and radiographical changes after lumbar implantation of the PEEK nonfusion interspinous device in the BB.4S rat model. Spine. 38 (5): pp. E263-E269.
    Source Title
    Spine
    DOI
    10.1097/BRS.0b013e318280c710
    ISSN
    0362-2436
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/34137
    Collection
    • Curtin Research Publications
    Abstract

    STUDY DESIGN. An experimental animal study. OBJECTIVE. To investigate histomorphometric and radiographical changes in the BB.4S rat model after PEEK (polyetheretherketone) nonfusion interspinous device implantation. SUMMARY OF BACKGROUND DATA. Clinical effectiveness of the PEEK nonfusion spine implant Wallis (Abbott, Bordeaux, France; now Zimmer, Warsaw, IN) is well documented. However, there is a lack of evidence on the long-term effects of this implant on bone, in particular its influence on structural changes of bone elements of the lumbar spine. METHODS. Twenty-four male BB.4S rats aged 11 weeks underwent surgery for implantation of a PEEK nonfusion interspinous device or for a sham procedure in 3 groups of 8 animals each: 1) implantation at level L4-L5; 2) implantation at level L5-L6; and 3) sham surgery. Eleven weeks postoperatively osteolyses at the implant-bone interface were measured via radiograph, bone mineral density of vertebral bodies was analyzed using osteodensitometry, and bone mineral content as well as resorption of the spinous processes were examined by histomorphometry. RESULTS. Resorption of the spinous processes at the site of the interspinous implant was found in all treated segments. There was no significant difference in either bone density of vertebral bodies or histomorphometric structure of the spinous processes between adjacent vertebral bodies, between treated and untreated segments and between groups. CONCLUSION. These findings indicate that resorption of spinous processes because of a result of implant loosening, inhibit the targeted load redistribution through the PEEK nonfusion interspinous device in the lumbar spinal segment of the rat. This leads to reduced long-term stability of the implant in the animal model. These results suggest that PEEK nonfusion interspinous devices like the Wallis implants may have time-limited effects and should only be used for specified indications. © 2013, Lippincott Williams & Wilkins.

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