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    Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver

    Access Status
    Open access via publisher
    Authors
    Gani, R.
    Yunihastuti, E.
    Krishnuhoni, E.
    Saraswati, H.
    Djauzi, S.
    Lesmana, L.
    Lee, S.
    Price, Patricia
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Gani, R. and Yunihastuti, E. and Krishnuhoni, E. and Saraswati, H. and Djauzi, S. and Lesmana, L. and Lee, S. et al. 2014. Periportal CD4+ Cell Infiltration Increases in HIV/Hepatitis C Virus–Coinfected Patients Commencing ART, Whereas CD8+ Cells Clear From the Liver. Journal of Infectious Diseases. 210 (3): pp. 405-409.
    Source Title
    Journal of Infectious Diseases
    DOI
    10.1093/infdis/jiu118
    ISSN
    0022-1899
    URI
    http://hdl.handle.net/20.500.11937/34325
    Collection
    • Curtin Research Publications
    Abstract

    Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common in Asia, but the effects of antiretroviral therapy (ART) are unclear. Histopathological changes in the liver are described in a prospective study of HCV-seropositive HIV-infected patients at Cipto Mangunkusomo Hospital (Jakarta, Indonesia). Liver biopsy specimens were collected at baseline (n = 48) and 48 weeks (n = 34). Ishak scores showed mild but detectable inflammation and/ or fibrosis. Levels of portal inflammation declined during ART (P = .03), whereas fibrosis remained (P = .11). Portal infiltration of CD4+ cells increased during ART (P < .0001), whereas infiltration of CD8+ cells subsided. Numbers of CD4+ cells in the liver at baseline correlated with circulating CD4+ T-cell counts (P = .03–.05). Numbers of liver-infiltrating CD4+ and CD8+ cells at baseline were not associates with subsequent experience of an immune restoration disease, which is defined by a rise in alanine transaminase levels during ART.

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