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    Non-canonical peptides bound to MHC

    Access Status
    Fulltext not available
    Authors
    Day, S.
    Ramsland, Paul
    Apostolopoulos, V.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Day, S. and Ramsland, P. and Apostolopoulos, V. 2009. Non-canonical peptides bound to MHC. Current Pharmaceutical Design. 15 (28): pp. 3274-3282.
    Source Title
    Current Pharmaceutical Design
    DOI
    10.2174/138161209789105090
    ISSN
    1381-6128
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/35489
    Collection
    • Curtin Research Publications
    Abstract

    Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies. © 2009 Bentham Science Publishers Ltd.

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