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dc.contributor.authorDay, S.
dc.contributor.authorRamsland, Paul
dc.contributor.authorApostolopoulos, V.
dc.identifier.citationDay, S. and Ramsland, P. and Apostolopoulos, V. 2009. Non-canonical peptides bound to MHC. Current Pharmaceutical Design. 15 (28): pp. 3274-3282.

Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies. © 2009 Bentham Science Publishers Ltd.

dc.titleNon-canonical peptides bound to MHC
dc.typeJournal Article
dcterms.source.titleCurrent Pharmaceutical Design
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

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