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Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study

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Authors
Wadley, A.
Lombard, Z.
Cherry, C.
Price, Patricia
Kamerman, P.
Date
2012
Type
Journal Article

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Wadley, A. and Lombard, Z. and Cherry, C. and Price, P. and Kamerman, P. 2012. Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association study. Journal of Acquired Immune Deficiency Syndromes. 60 (1): pp. 20-23.
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Journal of Acquired Immune Deficiency Syndromes
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School of Biomedical Sciences
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Abstract

We analyzed GTP cyclohydrolase 1 in symptomatic HIV-associated sensory neuropathy in Southern Africans including a "painprotective" 3-SNP haplotype and 6 SNPs, analyzed individually and in a 6-SNP haplotype. The "pain-protective" 3-SNP haplotype and a 6-SNP haplotype containing these alleles associated with a reduced risk of pain. Another 3-SNP haplotype associated with increased presence of pain. Associations were lost after correction for age, gender, and CD4 T-cell count. Linkage disequilibrium differed between our cohort and Caucasians suggesting that these SNPs may not be ideal markers in Africans. Subsequently, the role of GTP cyclohydrolase 1 in painful HIV-associated sensory neuropathy remains possible. Copyright © 2012 by Lippincott Williams & Wilkins.