Show simple item record

dc.contributor.authorPanahifar, A.
dc.contributor.authorMahmoudi, M.
dc.contributor.authorDoschak, Michael
dc.date.accessioned2017-01-30T13:53:36Z
dc.date.available2017-01-30T13:53:36Z
dc.date.created2013-11-19T20:00:38Z
dc.date.issued2013
dc.identifier.citationPanahifar, Arash and Mahmoudi, Morteza and Doschak, Michael R. 2013. Synthesis and in vitro evaluation of bone-seeking superparamagnetic iron oxide nanoparticles as contrast agents for imaging bone metabolic activity. ACS Applied Materials and Interfaces. 5 (11): pp. 5219-5226.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/36090
dc.identifier.doi10.1021/am4010495
dc.description.abstract

In this article, we report the synthesis and in vitro evaluation of a new class of nonionizing bone-targeting contrast agents based on bisphosphonate-conjugated superparamagnetic iron oxide nanoparticles (SPIONs), for use in imaging of bone turnover with magnetic resonance imaging (MRI). Similar to bone-targeting 99mTechnetium medronate, our novel contrast agent uses bisphosphonates to impart bone-seeking properties, but replaces the former radioisotope with nonionizing SPIONs which enables their subsequent detection using MRI. Our reported method is relatively simple, quick and cost-effective and results in BP-SPIONs with a final nanoparticle size of 17 nm under electron microscopy technique (i.e., TEM). In-vitro binding studies of our novel bone tracer have shown selective binding affinity (around 65%) for hydroxyapatite, the principal mineral of bone. Bone-targeting SPIONs offer the potential for use as nonionizing MRI contrast agents capable of imaging dynamic bone turnover, for use in the diagnosis and monitoring of metabolic bone diseases and related bone pathology.

dc.publisherAmerican Chemical Society
dc.subjectcontrast agent
dc.subjectbisphosphonate
dc.subjectsuperparamagnetic iron oxide nanoparticles
dc.subjectselective binding
dc.subjectMRI
dc.subjectbone
dc.subjectdiagnosis
dc.subjectosteoarthritis
dc.titleSynthesis and in vitro evaluation of bone-seeking superparamagnetic iron oxide nanoparticles as contrast agents for imaging bone metabolic activity
dc.typeJournal Article
dcterms.source.volume5
dcterms.source.number11
dcterms.source.startPage5219
dcterms.source.endPage5226
dcterms.source.issn1944-8244
dcterms.source.titleACS Applied Materials and Interfaces
curtin.department
curtin.accessStatusFulltext not available


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record