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    Lower Fructose Intake May Help Protect Against Development of Nonalcoholic Fatty Liver in Adolescents With Obesity

    225191_225191.pdf (348.6Kb)
    Access Status
    Open access
    Authors
    O'Sullivan, T.
    Oddy, W.
    Bremner, A.
    Sherriff, Jill
    Ayonrinde, Oyekayo
    Olynyk, John
    Beilin, L.
    Mori, T.
    Adams, L.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    O'Sullivan, T. and Oddy, W. and Bremner, A. and Sherriff, J. and Ayonrinde, O. and Olynyk, J. and Beilin, L. et al. 2014. Lower Fructose Intake May Help Protect Against Development of Nonalcoholic Fatty Liver in Adolescents With Obesity. Journal of Pediatric Gastroenterology and Nutrition. 58 (5): pp. 624-631.
    Source Title
    Journal of Pediatric Gastroenterology and Nutrition
    DOI
    10.1097/MPG.0000000000000267
    ISSN
    0277-2116
    Remarks

    This is a non-final version of an article published in final form in Journal of Pediatric Gastroenterology and Nutrition. 58 (5): pp. 624-631.

    URI
    http://hdl.handle.net/20.500.11937/36297
    Collection
    • Curtin Research Publications
    Abstract

    Objectives: Although obesity is a major risk factor for nonalcoholic fatty liver (NAFL), not all individuals with obesity develop the condition, suggesting that other factors such as diet may also contribute to NAFL development. We evaluated associations between fructose and total sugar intake and subsequent diagnosis of NAFL in adolescents with obesity and without obesity in a population-based cohort. Methods: Adolescents participating in the Western Australian Pregnancy Cohort (Raine) Study completed 3-day food records and body mass index measurement at age 14 years. At age 17 years, participants underwent abdominal ultrasound to determine NAFL status. Multivariable logistic regression models were used to analyse associations between energy-adjusted fructose and total sugar intake and NAFL status. Food diaries and liver assessments were completed for 592 adolescents.Results: The prevalence of NAFL at age 17 was 12.8% for the total group and 50% for adolescents with obesity. Fructose intake did not significantly differ between adolescents with or without NAFL in our cohort as a whole. Among adolescents with obesity, those without NAFL had significantly lower energy-adjusted fructose intake at age 14 years compared with those with NAFL (mean ± standard deviation [SD] 38.8 ± 19.8 g/day, vs 55.7 ± 14.4 g/day, P = 0.02). Energy-adjusted fructose intake was independently associated with NAFL in adolescents with obesity (OR [odds ratio] 1.09, 95% CI 1.01–1.19, P = 0.03) after the adjustment for confounding factors. Energy-adjusted total sugar intake showed less significance (OR 1.03, 95% CI 0.999–1.07, P = 0.06). No significant associations were observed in other body mass index categories. Conclusions: Lower fructose consumption in adolescents with obesity at 14 years is associated with a decreased risk of NAFL at 17 years. Fructose rather than overall sugar intake may be more physiologically relevant in this association.

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