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dc.contributor.authorBailey, H.
dc.contributor.authorFritschi, Lin
dc.contributor.authorInfante-Rivard, C.
dc.contributor.authorGlass, D.
dc.contributor.authorMiligi, L.
dc.contributor.authorDockerty, J.
dc.contributor.authorLightfoot, T.
dc.contributor.authorClavel, J.
dc.contributor.authorRoman, E.
dc.contributor.authorSpector, L.
dc.contributor.authorKaatsch, P.
dc.contributor.authorMetayer, C.
dc.contributor.authorMagnani, C.
dc.contributor.authorMilne, Elizabeth
dc.contributor.authorPolychronopoulou, S.
dc.contributor.authorSimpson, J.
dc.contributor.authorRudant, J.
dc.contributor.authorSidi, V.
dc.contributor.authorRondelli, R.
dc.contributor.authorOrsi, L.
dc.contributor.authorKang, A.
dc.contributor.authorPetridou, E.
dc.contributor.authorSchuz, J.
dc.date.accessioned2017-01-30T13:56:11Z
dc.date.available2017-01-30T13:56:11Z
dc.date.created2014-10-14T20:00:17Z
dc.date.issued2014
dc.identifier.citationBailey, H. and Fritschi, L. and Infante-Rivard, C. and Glass, D. and Miligi, L. and Dockerty, J. and Lightfoot, T. et al. 2014. Parental Occupational Pesticide Exposure and the Risk of Childhood Leukemia in the Offspring: Findings From the Childhood Leukemia International Consortium. International Journal of Cancer. 135 (9): pp. 2157-2172.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/36529
dc.identifier.doi10.1002/ijc.28854
dc.description.abstract

Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms.

dc.publisherJohn Wiley & Sons, Inc.
dc.subjectpesticide
dc.subjectmeta-analysis
dc.subjectoccupation
dc.subjectleukemia
dc.subjectpooled analysis
dc.subjectchildhood
dc.titleParental Occupational Pesticide Exposure and the Risk of Childhood Leukemia in the Offspring: Findings From the Childhood Leukemia International Consortium
dc.typeJournal Article
dcterms.source.volume135
dcterms.source.startPage2157
dcterms.source.endPage2172
dcterms.source.issn0020-7136
dcterms.source.titleInternational Journal of Cancer
curtin.note

This is the accepted version of the following article: Bailey, H. and Fritschi, L. and Infante-Rivard, C. and Glass, D. and Miligi, L. and Dockerty, J. and Lightfoot, T. et al. 2014. Parental Occupational Pesticide Exposure and the Risk of Childhood Leukemia in the Offspring: Findings From the Childhood Leukemia International Consortium. International Journal of Cancer. 135 (9): pp. 2157-2172, which has been published in final form at http://doi.org/10.1002/ijc.28854

curtin.departmentSchool of Public Health
curtin.accessStatusOpen access


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