Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation

    Access Status
    Fulltext not available
    Authors
    Desai, Chirag
    Wood, F.
    Schug, S.
    Parsons, Richard
    Fridlender, C.
    Sunderland, Vivian Bruce
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Desai, Chiragkumar and Wood, Fiona M. and Schug, Stephan A. and Parsons, Richard W. and Fridlender, Charles and Sunderland, Vivian Bruce. 2014. Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: A double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation. Burns. 40 (1): pp. 106-112.
    Source Title
    Burns
    DOI
    10.1016/j.burns.2013.05.013
    ISSN
    0305-4179
    URI
    http://hdl.handle.net/20.500.11937/36859
    Collection
    • Curtin Research Publications
    Abstract

    Background: Partial thickness skin graft wounds are painful. Topically applied lidocaine has been used for analgesia in several clinical trials. This study compared the effectiveness of two different formulations of topical local anaesthetic for dressing changes of partial thickness skin graft donor sites.Methods: A double-blind randomised controlled, pilot trial was conducted in 29 patients undergoing split thickness skin graft surgery. Subjects were randomised to either a 3% lidocaine emulsion formulation ‘‘Treatment E’’ (NOPAYNETM) or a 4% aqueous solution ‘‘Treatment A’’ (XylocaineTM). Subjects received one spray per 3 cm2 of donor site area followed by up to two further spays as required. Endpoints included pain intensity measured by the numerical rating scale (NRS) up to 1 h after dressing change commencement, sting sensation, overall satisfaction and lidocaine plasma concentration.Results: The 60 min pain scores for E and A were 1.3 ±0.3 (mean ±SEM) and 1.8 ±0.4 (ƿ = 0.98) respectively. Nearly 90% of patients were very satisfied with their treatment. The mean plasma concentrations of lidocaine for A and E were 0.132 mg/l and 0.040 mg/l respectively (ƿ = 0.069).Conclusion: The topical local anaesthetic formulations achieved low pain scores during dressing changes. The safety profile was potentially improved with the emulsion formulation of lidocaine.

    Related items

    Showing items related by title, author, creator and subject.

    • Solubility studies of prilocaine and lignocaine with Hydroxy-Propyl beta Cyclodextrin
      Munot, Vaishaali (2007)
      Formulation of local anaesthetics in different dosage forms, including those for oral, parenteral, and topical application have being widely investigated. All of these formulations include local anaesthetics in their salt ...
    • A randomised pilot equivalence trial to evaluate diamagnetically enhanced transdermal delivery of key ground substance components in comparison to an established transdermal non-steroidal anti-inflammatory formulation in males with prior knee injury
      Vicenzino, B.; Lawrenson, P.; Khan, A.; Stephenson, A.; Heales, L.; Benson, Heather ; Wright, Tony (2019)
      Objective: This pilot study assessed the efficacy of a knee guard device, which used magnetophoresis to transdermally deliver Glucosamine, Chondroitin and Hyaluronic Acid in a cohort of individuals with prior knee injury. ...
    • Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment
      Leite-Silva, V.; Sanchez, W.; Studier, H.; Liu, D.; Mohammed, Y.; Holmes, A.; Ryan, E.; Haridass, I.; Chandrasekaran, N.; Becker, W.; Grice, J.; Benson, Heather; Roberts, M. (2016)
      Public health concerns continue to exist over the safety of zinc oxide nanoparticles that are commonly used in sunscreen formulations. In this work, we assessed the effects of two conditions which may be encountered in ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.