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dc.contributor.authorCowin, G.
dc.contributor.authorButler, T.
dc.contributor.authorKurniawan, N.
dc.contributor.authorWatson, Charles
dc.contributor.authorWallace, R.
dc.date.accessioned2017-01-30T14:02:23Z
dc.date.available2017-01-30T14:02:23Z
dc.date.created2012-04-02T20:00:43Z
dc.date.issued2011
dc.identifier.citationCowin, Gary J. and Butler, Tim J. and Kurniawan, Nyoman D. and Watson, Charles and Wallace, Robyn H. 2011. Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration. Neuro Image. 58 (1): pp. 69-74.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/37383
dc.identifier.doi10.1016/j.neuroimage.2011.06.003
dc.description.abstract

Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. Current imaging studies have concentrated on areas of the brain and spinal cord that contain mixed populations of sensory and motor neurons. In this study, ex vivo magnetic resonance microimaging (MRM) was used to separate motor and sensory components by visualizing individual dorsal and ventral roots in fixed spinal cords. MRM at 15 μm in plane resolution enabled the axons of pure populations of sensory and motor neurons to be measured in the lumbar region of the SOD1 mouse model of ALS. MRM signal intensity increased by 38.3% (p<0.05) exclusively in the ventral motor nerve roots of the lumbar spinal cord of ALS-affected SOD1mice compared to wild type littermates. The hyperintensity was therefore limited to white matter tracts arising from the motor neurons, whereas sensory white matter fibers were unchanged. Significant decreasesin ventral nerve root volume were also detected in the SOD1 mice, which correlated with the axonal degeneration observed by microscopy. These results demonstrate the usefulness of MRM in visualizing the ultrastructure of the mouse spinal cord. The detailed 3D anatomy allowed the processes of pure populations of sensory and motor neurons to be compared.

dc.publisherAcademic Press
dc.subjectamyotrophic lateral sclerosis
dc.subjectspinal cord magnetic resonance microimaging
dc.subjectSOD1
dc.titleMagnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration
dc.typeJournal Article
dcterms.source.volume58
dcterms.source.number1
dcterms.source.startPage69
dcterms.source.endPage74
dcterms.source.issn1053-8119
dcterms.source.titleNeuroImage
curtin.departmentAustralian Biosecurity CRC- Emerging Infectious Diseases (CRC-Core)
curtin.accessStatusFulltext not available


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